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Characterization of the B-Raf interactome in mouse hippocampal neuronal cells
(Elsevier Science, 2011-02)
B-Raf links a variety of extracellular stimuli downstream of cell surface receptors, constituting a determining factor in the ability of neurons to activate ERK. A detailed study of the B-Raf interactome is necessary to ...
Alterations of the extracellular matrix of lung during zinc deficiency
(Cambridge University Press, 2012-07)
Suboptimal intake of Zn is one of the most common nutritional problems worldwide. Previously, we have shown that Zn deficiency (ZD) produces oxidative and nitrosative stress in the lung of rats. We analyse the effect of ...
Extracellular-regulated kinase and p38 mitogen-activated protein kinases are involved in the antiapoptotic action of 17β-estradiol in skeletal muscle cells
(BioScientifica, 2010-08)
17β-Estradiol (E2) stimulates the mitogen-activated protein kinases (MAPKs) in various cellular types.We have shown that the hormone activates extracellular-regulated kinase (ERK) and p38 MAPK in skeletal muscle cells. ...
Cannabinoid receptor type 1 agonist ACEA improves motor recovery and protects neurons in ischemic stroke in mice
(Wiley, 2015-11)
Brain ischemia produces neuronal cell death and the recruitment of pro-inflammatory cells. In turn, the search for neuroprotection against this type of insult has rendered results involving a beneficial role of endocannabinoid ...
Estrogen receptor-α promotes endothelial cell motility through focal adhesion kinase
(Oxford University Press, 2011-04)
Sex steroids play a key role in cell movement and tissue organization. Cell migration requires the integration of events that induce changes in cell structure such as protrusion, polarization and traction toward the direction ...
Plasticity in the rat prefrontal cortex: linking gene expression and an operant learning with a computational theory
(Public Library of Science, 2010-01)
The plasticity in the medial Prefrontal Cortex (mPFC) of rodents or lateral prefrontal cortex in non human primates (lPFC), plays a key role neural circuits involved in learning and memory. Several genes, like brain-derived ...
Aquaporin-1 plays a key role in erythropoietin-induced endothelial cell migration
(Elsevier Science, 2019-10)
Water influx through aquaporin-1 (AQP-1) has been linked to the ability of different cell types to migrate, and therefore plays an important part in processes like metastasis and angiogenesis. Since the erythroid growth ...
Immunophilins FKBP51 and FKBP52
(MDPI, 2019)
Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-isomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) ...
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4
(Rockefeller University Press, 2021-02)
In stressed cells, phosphorylation of eukaryotic initiation factor 2α (eIF2α) controls transcriptome-wide changes in mRNA translation and gene expression known as the integrated stress response. We show here that DCs are ...
Selective hemangioma cell dysfunction and apoptosis triggered by in vitro treatment with imiquimod
(Elsevier Ireland, 2018-05)
Infantile hemangiomas are the most common benign tumors of infancy, characterized by unregulated angiogenesis and endothelial cells with high mitotic rate. Although spontaneous regression occurs, sometimes treatment is ...