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Neutral dynamics and cell renewal of colonic crypts in homeostatic regime
(IOP Publishing, 2018-03-01)
The self renewal process in colonic crypts is the object of several studies. We present here a new compartment model with the following characteristics: (a) we distinguish different classes of cells: stem cells, six ...
The disruptive effect of lysozyme on the bacterial cell wall explored by an in-silico structural outlook
(John Wiley & Sons Inc, 2018-01)
The bacterial cell wall, a structural unit of peptidoglycan polymer comprised of glycan strands consisting of a repeating disaccharide motif [N-acetylglucosamine (NAG) and N-acetylmuramylpentapeptide (NAM pentapeptide)], ...
On the discovery of a potential survivin inhibitor combining computational tools and cytotoxicity studies
(Elsevier, 2019-08-01)
Survivin protein is a metalloprotein member of the inhibitors of apoptosis proteins family, involved in the regulation of programmed cell death. Due to the recent development of antitumor therapies having survivin as ...
TRPC6 Binds to and activates calpain, independent of its channel activity, and regulates podocyte cytoskeleton, cell adhesion, and motility
(Synthesis-Stuttgart, 2019-10)
Background Mutations in the transient receptor potential channel 6 (TRPC6) gene are associated with an inherited form of FSGS. Despite widespread expression, patients with TRPC6 mutations do not present with any other ...
From cartoons to quantitative models in Golgi transport
(Journal of the Serbian Chemical Society, 2020-12)
Background: Cell biology is evolving to become a more formal and quantitative science. In particular, several mathematical models have been proposed to address Golgi self-organisation and protein and lipid transport. ...
Mass Spectrometry-Based Metabolic Fingerprinting Contributes to Unveil the Role of RSUME in Renal Cell Carcinoma Cell Metabolism
(American Chemical Society, 2020-10)
Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with 50-80% patients exhibiting mutations in the von Hippel-Lindau (VHL) gene. RSUME (RWD domain (termed after three major RWD-containing proteins: RING ...
Modulatory effects of ghrelin on sperm quality alterations induced by a fructose-enriched diet
(Elsevier Ltd, 2019-11)
The objectives of this study were: 1) to evaluate the effects of a fructose enriched diet (FED) on rat3 sperm quality, epididymal function (i.e. oxidative stress and alpha-glucosidase expression) and4 testosterone ...
Epithelial Sodium Channel in a Human Trophoblast Cell Line (BeWo)
(Springer, 2008-06)
The present study was performed to assay sodium currents in BeWo cells. These cells comprise a human trophoblast cell line which displays many of the biochemical and morphological properties similar to those reported for ...
A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the vestigial expression pattern
(Academic Press Inc Elsevier Science, 2020-06-15)
Organs mainly attain their size by cell growth and proliferation, but sometimes also grow through recruitment of undifferentiated cells. Here we investigate the participation of cell recruitment in establishing the pattern ...
Neurotrophic factor NT-3 displays a non-canonical cell guidance signaling function for cephalic neural crest cells
(Elsevier Gmbh, 2013-11)
Chemotactic cell migration is triggered by extracellular concentration gradients of molecules segregated by target fields. Neural crest cells (NCCs), paradigmatic as an accurately moving cell population, undergo wide ...