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Neuroprotective effects of hypothermia on synaptic actin cytoskeletal changes induced by perinatal asphyxia
(Elsevier Science, 2014-05)
Cerebral hypoxia–ischemia damages synaptic proteins, resulting in cytoskeletal alterations, protein aggregation and neuronal death. In the previous works, we have shown neuronal and synaptic changes in rat neostriatum ...
Wnt-5a/frizzled9 receptor signaling through the Gαo-Gβγ complex regulates dendritic spine formation
(American Society for Biochemistry and Molecular Biology, 2016-09)
Wnt ligands play crucial roles in the development and regulation of synapse structure and function. Specifically, Wnt-5a acts as a secreted growth factor that regulates dendritic spine formation in rodent hippocampal ...
SIRT-1 Activity Sustains Cholesterol Synthesis in the Brain
(Pergamon-Elsevier Science Ltd, 2021-11)
SIRT-1 is a potent energy regulator that has been implicated in the aging of different tissues, and cholesterol synthesis demands high amounts of cellular adenosine triphosphate. An efficient synaptic transmission depends ...
Life and Work of Stress Granules and Processing Bodies: New Insights into Their Formation and Function
(American Chemical Society, 2018-05)
The dynamic formation of stress granules (SGs), processing bodies (PBs), and related RNA organelles regulates diverse cellular processes, including the coordination of functionally connected messengers, the translational ...
Transmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies
(Society for Neuroscience, 2012-11)
The auditory system processes time and intensity through separate brainstem pathways to derive spatial location as well as other salient features of sound. The independent coding of time and intensity begins in the cochlea, ...
Rearrangements under confinement lead to increased binding energy of Synaptotagmin-1 with anionic membranes in Mg2+ and Ca2+
(Elsevier Science, 2018-04)
Synaptotagmin-1 (Syt1) is the primary calcium sensor (Ca2+ ) that mediates neurotransmitter release at the synapse. The tandem C2 domains (C2A and C2B) of Syt1 exhibit functionally critical, Ca2+ -dependent interactions ...
Electrical properties and functional expression of ionic channels in cochlear inner hair cells of mice lacking the α10 nicotinic cholinergic receptor subunit
(Springer, 2009-06)
Cochlear inner hair cells (IHCs) release neurotransmitter onto afferent auditory nerve fibers in response to sound stimulation. During early development, synaptic transmission is triggered by spontaneous Ca2+ spikes which ...
Inner Ear Genes Underwent Positive Selection and Adaptation in the Mammalian Lineage
(Oxford University Press, 2019-08)
The mammalian inner ear possesses functional and morphological innovations that contribute to its unique hearing capacities. The genetic bases underlying the evolution of this mammalian landmark are poorly understood. We ...
Changes in motor function and brain cortex mitochondrial active oxygen species production in aged mice
(Pergamon-Elsevier Science Ltd, 2019-04)
Neuronal ageing is a complex physiological process, associated to metabolic and motor changes. In this study, 3 and 17 months old male Swiss mice were used. Aged mice exhibited a significant reduction in motor performance ...
Synaptic control of local translation: the plot thickens with new characters
(Springer, 2013-11)
The production of proteins from mRNAs localized at the synapse ultimately controls the strength of synaptic transmission, thereby affecting behavior and cognitive functions. The regulated transcription, processing, and ...