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The evolution of signal-reward correlations in bee- and hummingbirdpollinated species of Salvia
(The Royal Society, 2014-03)
Within-individual variation in floral advertising and reward traits is a feature experienced by pollinators that visit different flowers of the same plant. Pollinators can use advertising traits to gather information about ...
Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice
(Elsevier Science, 2002-06)
The autoimmune sialadenitis developed by non-obese diabetic (NOD) mice is considered a suitable model to study the ethiopathogenic mechanisms leading to sicca symptoms in Sjo¨gren’s syndrome (SS). Evidence supporting a ...
Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations
(Public Library of Science, 2017-06)
Ultrasensitive response motifs, capable of converting graded stimuli into binary responses, are well-conserved in signal transduction networks. Although it has been shown that a cascade arrangement of multiple ultrasensitive ...
Ubiquitin-proteasome signaling in lung injury
(Elsevier Science Inc., 2018-08)
Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases ...
Synthesis of multiport resistors with piecewise-linear characteristics: a mixed-signal architecture
(John Wiley & Sons Ltd, 2005-07)
Non‐linear multiport resistors are the main ingredients in the synthesis of non‐linear circuits. Recently, a particular PWL representation has been proposed as a generic design platform (IEEE Trans. Circuits Syst.‐I 2002; ...
Tankyrase inhibitors hinder Trypanosoma cruzi infection by altering host-cell signalling pathways
(Cambridge University Press, 2021-09)
Chagas disease is a potentially life-threatening protozoan infection affecting around 8 million people, for which only chemotherapies with limited efficacy and severe adverse secondary effects are available. The etiological ...
Prefrontal cortex-driven dopamine signals in the striatum show unique spatial and pharmacological properties
(Society for Neuroscience, 2020-09-28)
Dopamine (DA) signals in the striatum are critical for a variety of vital processes, including motivation, motor learning, and reinforcement learning. Striatal DA signals can be evoked by direct activation of inputs from ...
Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
(Mary Ann Liebert, 2011-09)
p53 is a crucial transcription factor with tumor suppressive properties that elicits its function through specific target genes. It constitutes a pivotal system that integrates information received by many signaling pathways ...
Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway
(Wiley Blackwell Publishing, Inc, 2006-07-26)
Identifying the trophic factors for retina photoreceptors and the intracellular pathways activated to promote cell survival is crucial for treating retina neurodegenerative diseases. Docosahexaenoic acid (DHA), the major ...
Demyelination-remyelination in the CNS: ligand-dependent participation of the Notch signaling pathway
(Oxford University Press, 2019-06)
Multiple sclerosis (MS) is an immune-mediated central nervous system disease mostly affecting young people. Multiple sclerosis and other neurodegenerative and white matter disorders involve oligodendrocyte (OL) damage and ...