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Repurposing of host-based therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19): a link between antiviral and anticancer mechanisms?
(Elsevier Science, 2020-09)
Drug repurposing, also called repositioning or rediscovering, refers to the process of developing a known drug for a novel use that is different from its original clinical indication. This concept has focused great attention ...
Finding the simplest mechanistic kinetic model describing the homogeneous catalytic hydrogenation of avermectin to ivermectin
(American Chemical Society, 2011-04)
Six mechanistic kinetic models of increasing complexity are analyzed to describe the RhCl(Ph3P)3 catalyzed hydrogenation process to produce ivermectin from avermectins B1a and B1b. Global sensitivity analysis (GSA) usefulness ...
An attempt to replace an ivermectin-resistant Cooperia spp. population by a susceptible one on grazing pastures based on epidemiological principles and refugia management
(Elsevier Science, 2017-11)
The maintenance of anthelmintic-susceptible parasite refugia to delay the onset of anthelmintic resistance is an almost impossible effort in many grazing livestock production countries given that current refugia consist ...
Aquatic toxicity of ivermectin in cattle dung assessed using microcosms
(Academic Press Inc Elsevier Science, 2017-10)
Ivermectin (IVM) is a parasiticide widely used for livestock. It is a semisynthetic derivative of avermectin, a macrocyclic lactone produced by Streptomyces avermitilis. This drug is only partly metabolized by livestock; ...
Concentration and environmental fate of ivermectin in floodplain wetlands: an ecosystem approach
(Elsevier, 2020-03)
Ivermectin (IVM) is commonly used for broad control of endo- and ecto- parasites in cattle. In wetlands of the Parana Medio River, cattle has been treated repeatedly with IVM for years and concerns have been raised on ...
Análisis de eficacia antihelmíntica realizados por veterinarios en establecimientos bovinos de la región ganadera central
(Estación Experimental Agropecuaria General Villegas, INTA, 2021)
La parasitosis gastrointestinal es una de las enfermedades que mayor impacto económico ocasiona en los sistemas pastoriles de producción de carne bovina a nivel mundial (Charlier et al., 2015), principalmente por afectar ...
Modulation of the P-glycoprotein-mediated intestinal secretion of ivermectin: in vitro and in vivo assessments
(American Society for Pharmacology and Experimental Therapeutics, 2006-03)
The everted gut sac method was used to assess the role of the P-glycoprotein (P-gp) on the intestinal secretion of ivermectin (IVM), an antiparasitic widely used in human and veterinary medicine. The work included the ...
Albendazole and ivermectin for the control of soil-transmitted helminths in an area with high prevalence of Strongyloides stercoralis and hookworm in northwestern Argentina: A community-based pragmatic study
(Public Library of Science, 2017-10)
Background: Recommendations for soil-transmitted helminth (STH) control give a key role to deworming of school and pre-school age children with albendazole or mebendazole; which might be insufficient to achieve adequate ...
Eficacia del monepantel para el control de aislamientos de Haemonchus contortus y Trichostrongylus spp. con resistencia múltiple (ivermectina y febendazole) en caprinos
(Facultad de Ciencias Veterinarias de Esperanza, Universidad Nacional del Litoral, 2016)
El monepantel es un nuevo antihelmíntico registrado en nuestro país exclusivamente para el control de los nematodes gastrointestinales de los ovinos y su uso ha sido direccionado mayormente hacia el control de parásitos ...