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Evaluation of cell behavior on modified polypropylene with swift heavy ion irradiation
(Elsevier Science, 2012-02)
Ion beam irradiation is a well known means to change the physico-chemical properties of polymers, and induced bio and citocompatibility in controlled conditions and in selected areas of surface. However, the enhancement ...
Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms
(Elsevier, 2017-04)
Zinc deficiency affects the development of the central nervous system (CNS) through mechanisms only partially understood. We previously showed that zinc deficiency causes CNS oxidative stress, damaging microtubules and ...
New actors in optic neuritis pathogenesis
(Wiley Blackwell Publishing, Inc, 2020-03)
The aim of the present report was to analyze the involvement of glutamate neurotoxicity in retinal ganglion cell loss and optic nerve damage induced by experimental optic neuritis. For this purpose, the authors used an ...
Actin filaments-A target for redox regulation
(John Wiley and Sons Inc., 2016-10)
Actin and its ability to polymerize into dynamic filaments is critical for the form and function of cells throughout the body. While multiple proteins have been characterized as affecting actin dynamics through noncovalent ...
Regulación de la Calcio ATPasa de membrana plasmática por el citoesqueleto de actina
(Academia Nacional de Farmacia y Bioquímica, 2018-06)
Las asociaciones entre los componentes de la membrana plasmática y el citoesqueleto cortical son consideradas ya no sólo de naturaleza estructural y mecánica sino que hoy en día son reconocidas como interacciones dinámicas ...
Galectin-3 Exerts a Pro-differentiating and Pro-myelinating Effect Within a Temporal Window Spanning Precursors and Pre-oligodendrocytes: Insights into the Mechanisms of Action
(Humana Press, 2019-10)
Oligodendrocytes (OLG) are the cells resident in the CNS responsible for myelination. OLG undergo a succession of morphological and molecular changes along several maturational stages. Galectin-3 (Gal-3) is a 25- to 35-KDa ...
Direct effects of ethanol on neuronal differentiation: An in vitro analysis of viability and morphology
(Pergamon-Elsevier Science Ltd, 2016-10)
The deleterious effects of ethanol (EtOH) on the brain have been widely described, but its effects on theneuronal cytoskeleton during differentiation have not yet been firmly established. In this context, ouraim was to ...
Bundles of Brain Microtubules Generate Electrical Oscillations
(Nature Publishing Group, 2018-12)
Microtubules (MTs) are long cylindrical structures of the cytoskeleton that control cell division, intracellular transport, and the shape of cells. MTs also form bundles, which are particularly prominent in neurons, where ...
Plasma membrane calcium ATPase activity is regulated by actin oligomers through direct interaction
(American Society for Biochemistry and Molecular Biology, 2013-08)
As recently described by our group, plasma membrane calcium ATPase (PMCA) activity can be regulated by the actin cytoskeleton. In this study, we characterize the interaction of purified G-actin with isolated PMCA and examine ...
Experimental virus evolution reveals a role of plant microtubule dynamics and TORTIFOLIA1/SPIRAL2 in RNA trafficking
(Public Library of Science, 2014-08)
The cytoskeleton is a dynamic network composed of filamentous polymers and regulatory proteins that provide a flexible structural scaffold to the cell and plays a fundamental role in developmental processes. Mutations that ...