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Ceramide 1-Phosphate Protects Endothelial Colony Forming Cells From Apoptosis and Increases Vasculogenesis In Vitro and In Vivo
(Lippincott Williams, 2019-08)
Objective: Ceramide 1-phosphate (C1P) is a bioactive sphingolipid highly augmented in damaged tissues. Because of its abilities to stimulate migration of murine bone marrow–derived progenitor cells, it has been suggested ...
Transcriptome Modifications in the Porcine Intramuscular Adipocytes during Differentiation and Exogenous Stimulation with TNF-α and Serotonin
(Molecular Diversity Preservation International, 2020-01-18)
Adipocytes are dynamic cells that have critical functions to maintain body energy homeostasis. Adipocyte physiology is affected by the adipogenic differentiation, cell program, as well as by the exogenous stimulation of ...
IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness
(Impact Journals, 2016-06)
New therapies are needed for advanced hepatocellular carcinoma (HCC) and the use of mesenchymal stromal cells (MSCs) carrying therapeutic genes is a promising strategy. HCC produce cytokines recruiting MSCs to the tumor ...
Transcriptional Induction of Periostin by a Sulfatase 2-TGFb1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma
(American Association for Cancer Research, 2017-02)
Existing antiangiogenic approaches to treat metastatic hepatocellular carcinoma (HCC) are weakly effectual, prompting further study of tumor angiogenesis in this disease setting. Here, we report a novel role for sulfatase ...
Prokaryotic RNA activates endothelial cells promoting neutrophil transmigration
(Nature Publishing Group, 2019-07)
Endothelial cell (EC)–neutrophil (PMN) interactions are crucial in the resolution of bacterial infections. Prokaryotic RNA (pRNA) has been reported as a pathogen‐associated molecular pattern that is released from bacteria ...
Photodynamic Modulation of Type 1 Interferon Pathway on Melanoma Cells Promotes Dendritic Cell Activation
(Frontiers Media S.A., 2019-11)
The immune response against cancer generated by type-I-interferons (IFN-1) has recently been described. Exogenous and endogenous IFN-α/β have an important role in immune surveillance and control of tumor development. In ...
Anticancer activity of repurposed hemostatic agent desmopressin on AVPR2‑expressing human osteosarcoma
(Spandidos Publications, 2021-03-26)
Osteosarcoma is the most prevalent primary bone malignancy. Due to its high aggressiveness, novel treatment strategies are urgently required to improve survival of patients with osteosarcoma, especially those with advanced ...
Oral administration of Linoleic acid induces new vessel formation and improves skin wound healing in diabetic rats
(Public Library of Science, 2016-10)
Introduction: Impaired wound healing has been widely reported in diabetes. Linoleic acid (LA) accelerates the skin wound healing process in non-diabetic rats. However, LA has not been tested in diabetic animals. Objectives: ...
Peptidyl‐Prolyl Isomerase Activity of Immunophilins Could Be the Mere Consequence of Protein Complex Organization
(John Wiley & Sons Inc, 2020-05)
Immunophilins comprise a family of proteins characterized by the presence of a specific sequence that usually shows peptidyl‐prolyl‐(cis/trans )‐isomerase (PPIase) activity, i.e., the reversible cis/trans interconversion ...