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Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells
(W J G Press, 2021-11-07)
Colorectal cancer (CRC) remains one of the leading causes of mortality from malignant diseases worldwide. In general terms, CRC presents high heterogeneity due to the influence of different genetic and environmental factors; ...
Kisspeptin and GnRH interactions in the reproductive brain of teleosts
(Academic Press Inc Elsevier Science, 2020-11-01)
It is well known that gonadotropin-releasing hormone (Gnrh) has a key role in reproduction by regulating the synthesis and release of gonadotropins from the anterior pituitary gland of all vertebrates. About 25 years ago, ...
Testicular anti-müllerian hormone: Clinical applications in DSD
(Thieme Medical Publ Inc, 2012-06)
Male fetal sexual differentiation of the genitalia is driven by Leydig cell-secreted androgens and Sertoli cell-secreted anti-Müllerian hormone (AMH). Disorders of sex development (DSD) may be due to abnormal morphogenesis ...
Gonadal hormone-independent sex differences in GABAA receptor activation in rat embryonic hypothalamic neurons
(Wiley Blackwell Publishing, Inc, 2020-03)
Background and Purpose: GABAA receptor functions are dependent on subunit composition, and, through their activation, GABA can exert trophic actions in immature neurons. Although several sex differences in GABA-mediated ...
Adverse effects induced by chromium VI, cadmium and arsenic exposure on hypothalamus-pituitary physiology
(Instituto de Histología y Embriología Dr. Mario H. Burgos (IHEM-CONICET), 2016-04)
Environmental contamination with some metalloids and heavy metals (M/HM) raises concern due to well known adverse effects on health. Among these pollutants, chromium VI (Cr VI), cadmium (Cd) and arsenic(As) are frequently ...
Humanin, a mitochondrial-derived peptide released by astrocytes, prevents synapse loss in hippocampal neurons
(Frontiers Media SA, 2019-05)
Astroglial cells are crucial for central nervous system (CNS) homeostasis. They undergo complex morpho-functional changes during aging and in response to hormonal milieu. Ovarian hormones positively affect different astroglia ...
Molecular actions of thyroid hormone on breast cancer cell migration and invasion via cortactin/n-WASP
(Frontiers Media S.A., 2019-03)
The thyroid hormone triiodothyronine (T3) plays a fundamental role in growth regulation, differentiation, metabolism and cellular movement. These processes are particularly important considering that deregulation of T3 ...
The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
(Karger, 2011-07)
Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as ...
Convergent signaling pathways regulate parathyroid hormone and fibroblast growth factor-23 action on NPT2A-mediated phosphate transport
(American Society for Biochemistry and Molecular Biology, 2016-09)
Parathyroid hormone (PTH) and FGF23 are the primary hormones regulating acute phosphate homeostasis. Human renal proximal tubule cells (RPTECs) were used to characterize the mechanism and signaling pathways of PTH and FGF23 ...
Extracellular-regulated kinase and p38 mitogen-activated protein kinases are involved in the antiapoptotic action of 17β-estradiol in skeletal muscle cells
(BioScientifica, 2010-08)
17β-Estradiol (E2) stimulates the mitogen-activated protein kinases (MAPKs) in various cellular types.We have shown that the hormone activates extracellular-regulated kinase (ERK) and p38 MAPK in skeletal muscle cells. ...