Buscar
Mostrando ítems 31-40 de 145
TRPC6 Binds to and activates calpain, independent of its channel activity, and regulates podocyte cytoskeleton, cell adhesion, and motility
(Synthesis-Stuttgart, 2019-10)
Background Mutations in the transient receptor potential channel 6 (TRPC6) gene are associated with an inherited form of FSGS. Despite widespread expression, patients with TRPC6 mutations do not present with any other ...
Heme oxygenase-1 in the forefront of a multi-molecular network that governs cell-cell contacts and filopodia-induced zippering in prostate cancer
(Nature Publishing Group, 2016-12)
Prostate cancer (PCa) cells display abnormal expression of cytoskeletal proteins resulting in an augmented capacity to resist chemotherapy and colonize distant organs. We have previously shown that heme oxygenase 1 (HO-1) ...
Telomere-led meiotic chromosome movements: recent update in structure and function
(Taylor & Francis, 2020-01)
In S. cerevisiae prophase meiotic chromosomes move by forces generated in the cytoplasm and transduced to the telomere via a protein complex located in the nuclear membrane. We know that chromosome movements require actin ...
Super-resolution imaging of live sperm reveals dynamic changes of the actin cytoskeleton during acrosomal exocytosis
(Company of Biologists, 2018-11)
Filamentous actin (F-actin) is a key factor in exocytosis in many cell types. In mammalian sperm, acrosomal exocytosis (denoted the acrosome reaction or AR), a special type of controlled secretion, is regulated by multiple ...
Disassembly of F-Actin Cytoskeleton after Interaction of Bacillus cereus with Fully Differentiated Human Intestinal Caco-2 Cells
(American Society for Microbiology, 2004-06)
In the present study the role of direct procaryote-eucaryote interactions in the virulence of Bacillus cereus has been investigated. As a model of human enterocytes, differentiated Caco-2 cells were used. Infection of fully ...
Extracellular matrix stiffness negatively affects axon elongation, growth cone area and F-actin levels in a collagen type I 3D culture
(John Wiley & Sons Ltd, 2021-11)
Three dimensional (3D) in vitro neuronal cultures can better reproduce physiologically relevant phenotypes compared to 2D-cultures, because in vivo neurons reside in a 3D microenvironment. Interest in neuronal 3D cultures ...
Mitogen-activated protein kinases are involved in hepatocanalicular dysfunction and cholestasis induced by oxidative stress
(Springer, 2017-06)
In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca2+-dependent protein kinase C isoforms (cPKC), ...
Actin filaments modulate electrical activity of brain microtubule protein two-dimensional sheets.
(Wiley Online Library, 2020-01)
The cytoskeleton of eukaryotic cells contains networks of actin filaments and microtubules (MTs) that are jointly implicated in various cell functions, including cell division, morphogenesis, and migration. In neurons, ...
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing
(Academic Press Inc Elsevier Science, 2020-07-11)
Long-term memory has been associated with morphological changes in the brain, which in turn tightly correlate with changes in synaptic efficacy. Such plasticity is proposed to rely on dendritic spines as a neuronal canvas ...
Extranuclear structural components that mediate dynamic chromosome movements in yeast meiosis
(Cell Press, 2020-04)
Telomere-led rapid chromosome movements or rapid prophase movements direct fundamental meiotic processes required for successful haploidization of the genome. Critical components of the machinery that generates rapid ...