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Canonical ErbB-2 isoform and ErbB-2 variant c located in the nucleus drive triple negative breast cancer growth
(Nature Publishing Group, 2020-04)
Triple negative breast cancer (TNBC) refers to tumors that do not express clinically significant levels of estrogen and progesterone receptors, and lack membrane overexpression or gene amplification of ErbB-2/HER2, a ...
A novel tilapia prolactin receptor is functionally distinct from its paralog
(Company of Biologists, 2009-06)
A novel tilapia prolactin (PRL) receptor (OmPRLR2) was identified based on its induction during hyperosmotic stress. OmPRLR2 protein shows 28% identity to tilapia OmPRLR1 and 26% identity to human PRLR. Comparison of OmPRLR1 ...
Ureide permease 5 (AtUPS5) connects cell compartments involved in UREIDE metabolism
(American Society of Plant Biologist, 2019-12)
Allantoin is a purine oxidative product involved in long distance transport of organic nitrogen in nodulating legumes and was recently shown to play a role in stress tolerance in other plants. The subcellular localization ...
The minicircular and extremely heteroplasmic mitogenome of the holoparasitic plant Rhopalocnemis phalloides
(Cell Press, 2021-12)
The plastid and nuclear genomes of parasitic plants exhibit deeply altered architectures,1–13 whereas the few examined mitogenomes range from deeply altered to conventional.14–20 To provide further insight on mitogenome ...
Functional studies of p.R132C, p.R149C, p.M283V, p.E431K, and a novel c.652-2A>G mutations of the CYP21A2 gene
(Public Library of Science, 2014-02)
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is the most frequent inborn error of metabolism and accounts for 90–95% of CAH cases. In the present work, we analyzed the functional consequence of ...
Thermomorphogenesis
(Annual Reviews, 2019-04)
When exposed to warmer, nonstressful average temperatures, some plant organs grow and develop at a faster rate without affecting their final dimensions. Other plant organs show specific changes in morphology or development ...
Growth hormone receptor gene polymorphism. Spontaneous catch up growth in small for gestational age patientsPolimorfismo del gen del receptor de la hormona de crecimiento. Crecimiento postnatal espontáneo en niños pequeños para la edad gestacional
(Medicina (Buenos Aires), 2021-10)
The growth hormone receptor (GHR) mediates the effect of growth hormone (GH) on linear growth and metabolism. In humans, it exists as two isoforms differing by the retention or exclusion of exon 3; a full-length GHR isoform ...
A118G Mu Opioid Receptor polymorphism increases inhibitory effects on Ca V2.2 channels
(Elsevier Ireland, 2012)
Hyperglycemia promotes overexpression of SR-BII isoform of the scavenger receptor class B type I in type 2 diabetes mellitus: A study in Juana Koslay City, San Luis, Argentina
(Scientific Research Publishing, 2013-10)
The scavenger receptor class B type I (SR-BI) is a high-density lipoprotein (HDL) receptor involved in reverse cholesterol transport. Some studies reported the association to be stronger in the presence of diabetes. The ...
Structure, target-specificity and expression of PN_LNC_N13, a long non-coding RNA differentially expressed in apomictic and sexual Paspalum notatum
(Springer, 2017-11)
Key message: ncRNA PN_LNC_N13 shows contrasting expression in reproductive organs of sexual and apomictic Paspalum notatum genotypes. Abstract: Apomictic plants set genetically maternal seeds whose embryos derive by ...