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Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling
(Elsevier Science, 2016-10)
Cytomegalovirus (CMV) is an opportunistic virus severely infecting immunocompromised individuals. In mice, endosomal Toll-like receptor 9 (TLR9) and downstream myeloid differentiation factor 88 (MyD88) are central to ...
Human pleural B-cells regulate IFN-γ production by local T-cells and NK cells in a Mycobacterium tuberculosis-induced delayed hypersensitivity reaction
(Portland Press, 2014-09)
DTH (delayed type hypersensitivity) reactions are secondary cellular immune responses that appear 24–72 h after antigen exposure. Tuberculous pleurisy is a common manifestation of extrapulmonary TB (tuberculosis) and is ...
Inhibition of EZH2 induces NK cell-mediated differentiation and death in invasive bladder cancer
(Nature Publishing Group, 2019-01)
Lysine-specific demethylase 6A (KDM6A) and members of the Switch/Sucrose Non-Fermentable (SWI/SNF) family are known to counteract the activity of Enhancer of Zeste Homolog 2 (EZH2), which is often overexpressed and is ...
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
(Nature Publishing Group, 2021-02-18)
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that have important homeostatic and disease-promoting functions1. However, little is known about the homeostatic anti-inflammatory ...
Auxotrophic mutant of Staphylococcus aureus interferes with nasal colonization by the wild type
(Elsevier Science, 2011-11)
Staphylococcus aureus nasal carriage is a risk factor for infection in humans, particularly in the hospital setting. Bacterial interference was used as an alternative strategy for the prevention of upper respiratory, ...
Immunomodulatory role of histamine H4 receptor in breast cancer
(Nature Publishing Group, 2019-01)
Background: Although the role of histamine H4 receptor (H4R) in immune cells is being extensively investigated, its immunomodulatory function in cancer is completely unknown. This study aimed to investigate the role of H4R ...
Modification of the HIV-specific CD8+ T-cell response in an HIV elite controller after chikungunya virus infection
(Lippincott Williams, 2016-04)
Objective: To evaluate the impact of chikungunya virus (CHIKV) infection on the quality of the HIV-specific CD8+ T-cell (CTL) response in an HIV elite controller. Design: Three blood samples were obtained from an elite ...
Zika virus infection of first trimester trophoblast cells affects cell migration, metabolism and immune homeostasis control
(Wiley-liss, div John Wiley & Sons Inc., 2020-12)
Zika virus (ZIKV) re-emerged after circulating almost undetected for many years and the last spread in 2015 was the major outbreak reported. ZIKV infection was associated with congenital fetal growth anomalies such as ...
Chronic Hepatitis C Pathogenesis: Immune Response in the Liver Microenvironment and Peripheral Compartment
(Frontiers Media, 2021-08)
Chronic hepatitis C (CHC) pathogenic mechanisms as well as the participation of the immune response in the generation of liver damage are still a topic of interest. Here, we evaluated immune cell populations and cytokines ...
Histamine H2 receptor in blood cells: a suitable target for the treatment of acute myeloid leukemia
(Springer, 2016-06-18)
Acute myeloid leukemia (AML) consists in a cancer of early hematopoietic cells arising in the bone marrow, most often of those cells that would turn into white blood cells (except lymphocytes). Chemotherapy is the treatment ...