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Intensive treatment with ivermectin and Iota carrageenan as pre-exposure prophylaxis for COVID-19 in health care workers from Tucuman, Argentina
(Lippincott Williams, 2021-08)
After COVID-19 emerged, a multitude of both novel and repurposed therapeutic agents were used empirically and studied in controlled clinical trials
First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina
(Elsevier, 2022-04)
Sheep scab, or psoroptic mange, a disease caused by the mite Psoroptes ovis, is commonly treated with ivermectin (IVM) and other macrocyclic lactones. In Argentina, in vivo trials have shown a decrease in IVM effectiveness ...
Ivermectin reduces in vivo coronavirus infection in a mouse experimental model
(Nature Research, 2021-03-30)
SARS-CoV2 is a single strand RNA virus member of the type 2 coronavirus family, responsible for causing COVID-19 disease in humans. The objective of this study was to test the ivermectin drug in a murine model of coronavirus ...
Cattle nematodes resistant to macrocyclic lactones: Comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin
(Academic Press Inc Elsevier Science, 2010-06)
The role of the drug efflux pump, known as P-glycoprotein, in the pharmacokinetic disposition (host) and resistance mechanisms (target parasites) of the macrocyclic lactone (ML) antiparasitic compounds has been demonstrated. ...
Presence of Syphacia muris in Wistar Rats of a Conventional Animal Care Facility and Treatment for the Eradication of this Parasitosis
(Acta Scientific Microbiology, 2020-08)
Laboratory animals are essential in research. Genetic and health quality control enables reliable and reproducible experimentaldata. A very common disease in rodent colony facilities, is a parasitosis caused by the etiological ...
Comparative tissue pharmacokinetics and efficacy of moxidectin, abamectin and ivermectin in lambs infected with resistant nematodes: Impact of drug treatments on parasite P-glycoprotein expression
(Elsevier, 2013-12)
The high level of resistance to the macrocyclic lactones has encouraged the search for strategies to optimize their potential as antiparasitic agents. There is a need for pharmaco-parasitological studies addressing the ...
Strongyloidiasis Outside Endemic Areas: Long-term Parasitological and Clinical Follow-up after Ivermectin Treatment
(University of Chicago Press, 2018-05)
Background Strongyloides stercoralis affects 30-100 million people worldwide. The first-line therapy is ivermectin. Cure is defined as the absence of larvae by parasitological methods 1 year after treatment. To date, no ...
Reply to Buonfrate and Bisoffi
(University of Chicago Press, 2018-08)
To the Editor ? We thank Drs Buonfrate and Bisof for reading our article. Our small long-term observational follow-up study included 21 ivermectin-treated patients; 14 of them presented with reactivation by larvae observation ...
Evidence of nuclear transport mechanisms in the protozoan parasite Giardia lamblia
(Elsevier Science, 2020-01)
Nuclear-cytoplasmic trafficking of proteins is a highly regulated process that modulates multiple biological processes in eukaryotic cells. In Giardia lamblia, shuttling has been described from the cytoplasm to nuclei of ...
Resistance of the cattle tick Rhipicephalus (Boophilus) microplus to ivermectin in Argentina
(Elsevier, 2020)
Resistance to ivermectin in populations of the cattle tick Rhipicephalus microplus in Argentina was diagnosed in this work. The in vitro larval immersion test (LIT) was used to determine quantitatively the levels of ...