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The actin/spectrin membrane-associated periodic skeleton in neurons
(Frontiers Research Foundation, 2018-05)
Neurons are the most asymmetric cell types, with their axons commonly extending over lengths that are thousand times longer than the diameter of the cell soma. Fluorescence nanoscopy has recently unveiled that actin, ...
A feed-forward mechanism involving the NOX complex and RyR-mediated ca2 + release during axonal specification
(Society for Neuroscience, 2016-10)
Physiological levels of ROS support neurite outgrowth and axonal specification, but the mechanisms by which ROS are able to shape neurons remain unknown. Ca2 +, a broad intracellular second messenger, promotes both Rac1 ...
Lipid raft-dependent adhesion of Giardia intestinalis trophozoites to a cultured human enterocyte-like Caco-2/TC7 cell monolayer leads to cytoskeleton-dependent functional injuries
(Wiley Blackwell Publishing, Inc, 2011-11)
Gardia intestinalis, the aetiological agent of giardiasis, one of the most common intestinal diseases in both developing and developed countries, induces a loss of epithelial barrier function and functional injuries of the ...
The actin cytoskeleton of the mouse sperm flagellum is organized in a helical structure
(Company of Biologists, 2018-06-11)
Conception in mammals is determined by the fusion of a sperm cell with an oocyte during fertilization. Motility is one of the features of sperm that allows them to succeed in fertilization, and their flagellum is essential ...
Estrogen regulates endometrial cell cytoskeletal remodeling and motility via focal adhesion kinase
(Elsevier Science Inc, 2011-02)
Objective: To explore the effects of 17β-estradiol (E2) on cytoskeletal remodeling and motility of endometrial stromal cells (ESC) and Ishikawa cells and to characterize the role of focal adhesion kinase (FAK) in these ...
The actin cytoskeleton participates in the early events of autophagosome formation upon starvation induced autophagy
(Landes Bioscience, 2012-08-06)
Autophagy is a process by which cytoplasmic material is sequestered in a double-membrane vesicle destined for degradation. Nutrient deprivation stimulates the pathway and the number of autophagosomes in the cell increases ...
Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53
(Frontiers Media, 2020-11)
Missense mutations in the TP53 gene are among the most frequent alterations in human cancer. Consequently, many tumors show high expression of p53 point mutants, which may acquire novel activities that contribute to develop ...
Galectin-3-mediated glial crosstalk drives oligodendrocyte differentiation and (Re)myelination
(Frontiers Media S.A., 2018-09)
Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD). The ...
The metalloprotease Mpl supports Listeria monocytogenes dissemination through resolution of membrane protrusions into vacuoles
(American Society for Microbiology, 2016-06)
Listeria monocytogenes is an intracellular pathogen that disseminates within the intestinal epithelium through acquisition of actin-based motility and formation of plasma membrane protrusions that project into adjacent ...
15-Deoxi-Δ12,14-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest
(Pergamon-Elsevier Science Ltd, 2009)