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Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration
(Nature Publishing Group, 2016-08)
There is substantial comorbidity between stress disorders and substance use disorders (SUDs), and acute stress augments the locomotor stimulant effect of cocaine in animal models. Here we endeavor to understand the neural ...
Modulation of extrasynaptic GABAergic receptor activity influences glutamate release and neuronal survival following excitotoxic damage to mouse spinal cord neurons
(Pergamon-Elsevier Science Ltd, 2019-09)
Excitotoxic levels of released glutamate trigger a cascade of deleterious cellular events leading to delayed neuronal death. This phenomenon implies extensive dysregulation in the balance between network excitation and ...
Effect of ionotropic and metabotropic glutamate agonists and D-aspartate on prolactin release from anterior pituitary cells
(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, 2002-03)
Although the presence of ionotropic (iGluRs) and metabotropic (mGluRs) glutamate receptors has been demonstrated in the anterior pituitary, recent reports on the direct effect of glutamate on prolactin (PRL) secretion by ...
GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment
(American Association for the Advancement of Science, 2014-09)
The lateral habenula (LHb), a key regulator of monoaminergic brain regions, is activated by negatively valenced events. Its hyperactivity is associated with depression. Although enhanced excitatory input to the LHb ...
Allopregnanolone and puberty: modulatory effect on glutamate and GABA release and expression of 3-hydroxysteroid oxidoreductase in the hypothalamus of female rats.
(Pergamon-Elsevier Science Ltd, 2013-04)
The hypothalamic release of glutamate and GABA regulates neurosecretory functions that may control the onset of puberty. This release may be influenced by neurosteroids such as allopregnanolone. Using superfusion experiments ...
Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome
(W J G Press, 2012-08)
Although new research technologies are constantly used to look either for genes or biomarkers in the prediction of metabolic syndrome (MS), the pathogenesis and pathophysiology of this complex disease remains a major ...
New cyanide-free alkaline electrolyte for the electrodeposition of Cu-Zn alloys using glutamate as complexing agent
(Electrochemical Society, 2019-01)
Glutamate is a potential replacement of cyanide in alkaline electrolytes due to its capability to form complexes with bivalent metal ions. Since promising results were achieved with copper and zinc plating baths, and the ...
Release of taurine and glutamate contributes to cell volume regulation in human retinal Müller cells: Differences in modulation by calcium
(American Physiological Society, 2018-09)
Neuronal activity in the retina generates osmotic gradients that lead to Müller cell swelling, followed by a regulatory volume decrease (RVD) response, partially due to the isoosmotic efflux of KCl and water. However, our ...