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Agonist Effects of Propranolol on Non-Tumor Human Breast Cells
(MDPI, 2020-04-22)
The β-blocker propranolol (PROP) has been proposed as a repurposed treatment for breast cancer. The similarity of action between β-agonists and antagonists found on breast cells encouraged us to compare PROP and isoproterenol ...
Inoculation site from a cutaneous melanoma patient treated with an allogeneic therapeutic vaccine: A case report
(Frontiers Media S.A., 2015-04)
We have developed a therapeutic vaccine consisting of a mixture of lethally-irradiated allogeneic cutaneous melanoma cell lines with BCG and GM-CSF as adjuvants. The CSF-470 vaccine is currently being assayed in a Phase ...
Reactive oxygen species in cancer: A paradox between pro- and anti-tumour activities
(Springer, 2020-07)
Cancer constitutes a group of heterogeneous diseases that share common features. They involve the existence of altered cellular pathways which result in uncontrolled cell proliferation. Deregulation of production and/or ...
Peri-operative biology in primary breast cancer: selective targeting of vasopressin type 2 receptor using desmopressin as a novel therapeutic approach
(Springer, 2016-06)
In breast cancer patients, surgical excision of the primary tumor is commonly the first step towards long-term control of disease progression. However, recent evidence suggests that surgery may also promote metastatic ...
PD-1/PD-L1 Pathway Modulates Macrophage Susceptibility to Mycobacterium tuberculosis Specific CD8+ T cell Induced DeathPD-1/PD-L1 Pathway Modulates Macrophage Susceptibility to Mycobacterium tuberculosis Specific CD8+ T cell Induced Death
(Nature Publishing GroupNature Publishing Group, 2019-01)
CD8+T cells contribute to tuberculosis (TB) infection control by inducing death of infected macrophages. Mycobacterium tuberculosis (Mtb) infection is associated with increased PD-1/PD-L1 expression and alternative activation ...
Delta-tocotrienol enhances the anti-tumor effects of interferon alpha through reactive oxygen species and Erk/MAPK signaling pathways in hepatocellular carcinoma cells
(National Research Council Canada-NRC Research Press, 2021-12)
The complexity of hepatocellular carcinoma (HCC) signaling and the failure of pharmacological therapeutics reveal the significance of establishing new anti-cancer strategies. Interferon alpha (IFN α) has been used as ...
Lactic Acid Bacteria Strains Differently Modulate Gut Microbiota and Metabolic and Immunological Parameters in High-Fat Diet-Fed Mice
(Frontiers Media, 2021-09)
Background: Dietary strategies, including the use of probiotics as preventive agents that modulate the gut microbiota and regulate the function of adipose tissue, are suitable tools for the prevention or amelioration of ...
Access of patients with breast and lung cancer to chemotherapy treatment in public and private hospitals in the city of Buenos Aires
(Oxford University Press, 2019-05)
Objectives: Describe the time elapsed from the diagnosis to treatment with chemotherapy for patients with breast and lung cancer at public and private hospitals in Buenos Aires. Design: Retrospective cohort study. Setting: ...
Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer
(Springer, 2017-04)
Purpose: Since combination of Toll-like receptor (TLR) ligands could boost antitumor immunity, we evaluated the efficacy of dendritic cell (DC) vaccines upon dual activation of TLR9 and TLR7 in breast cancer models. Methods: ...
Antimicrobial effect of a proteolytic enzyme from the fruits of Solanum granuloso-leprosum (dunal) against Helicobacter pylori
(Frontiers Media, 2021-12)
Helicobacter pylori is a gram-negative, helix-shaped, and microaerophilic bacteria that colonizes the human gastric mucosa, causing chronic infections, gastritis, peptic ulcer, lymphomas associated with lymphoid mucosa ...