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Extracellular Galectin-3 Induces Accelerated Oligodendroglial Differentiation Through Changes in Signaling Pathways and Cytoskeleton Dynamics
(Humana Press, 2019-01)
Galectin-3 (Gal-3) is a chimeric protein structurally composed of unusual tandem repeats of proline and short glycine-rich segments fused onto a carbohydrate recognition domain. Our studies have previously demonstrated ...
Actin cytoskeleton remodelling by sex steroids in neurones
(Wiley Blackwell Publishing, Inc, 2012-01)
Cell morphology and its interaction with the extracellular environment are integrated processes involving a number of intracellular controllers orchestrating cytoskeletal proteins and their interaction with the cell membrane ...
Apparent stiffness of vimentin intermediate filaments in living cells and its relation with other cytoskeletal polymers
(Elsevier Science, 2020-08)
The cytoskeleton is a complex network of interconnected biopolymers intimately involved in the generation and transmission of forces. Several mechanical properties of microtubules and actin filaments have been extensively ...
Ultrasensitivity in (SUPRA)molecularly organized and crowded environments
(Academic Press Ltd - Elsevier Science Ltd, 2001-12)
The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation ...
Glypican-3 regulates migration, adhesion and actin cytoskeleton organization in mammary tumor cells through Wnt signaling modulation
(Springer, 2008-04)
Glypican-3 (GPC3) is a proteoglycan involved in migration, proliferation and cell survival modulation in several tissues. There are many reports demonstrating a downregulation of GPC3 expression in some human tumors, ...
The inhibition of microtubule dynamics instability alters lipid homeostasis in TM4 Sertoli cells
(Academic Press Inc Elsevier Science, 2021-09-02)
Sertoli cells (SC) structurally support and transport nutrients to germ cells during spermatogenesis facilitated by an active cytoskeleton. Chemical perturbation of SC microtubule (MT) dynamics instability leads to premature ...
Proteomic analysis of the parasitic Cnidarian Ceratonova shasta (Cnidaria: Myxozoa) reveals diverse roles of actin in motility and spore formation
(Frontiers Media, 2021-04)
Myxozoans are widely distributed aquatic obligate endoparasites that were recently recognized as belonging within the phylum Cnidaria. They have complex life cycles with waterborne transmission stages: resistant, infectious ...
Morphological fluctuations of individual mitochondria in living cells
(IOP Publishing, 2022-03)
Uncovering the link between mitochondrial morphology, dynamics, positioning and function is challenging. Mitochondria are very flexible organelles that are subject to tension and compression within cells. Recent findings ...
Tuba activates cdc42 during neuronal polarization downstream of the small gtpase rab8a
(Society for Neuroscience, 2021-02)
The acquisition of neuronal polarity is a complex molecular process that depends on changes in cytoskeletal dynamics and directed membrane traffic, regulated by the Rho and Rab families of small GTPases, respectively. ...
Linoleic and oleic acids enhance cell migration by altering the dynamics of microtubules and the remodeling of the actin cytoskeleton at the leading edge
(Nature Publishing Group, 2021-12)
Fatty acids (FA) have a multitude of biological actions on living cells. A target of their action is cell motility, a process of critical importance during cancer cell dissemination. Here, we studied the effect of unsaturated ...