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Modelling phagosomal lipid networks that regulate actin assembly
(BioMed Central, 2008-12)
Background: When purified phagosomes are incubated in the presence of actin under appropriate conditions, microfilaments start growing from the membrane in a process that is affected by ATP and the lipid composition of the ...
The moonlighting protein c-Fos activates lipid synthesis in neurons, an activity that is critical for cellular differentiation and cortical development
(American Society for Biochemistry and Molecular Biology, 2020-06-26)
Differentiation of neuronal cells is crucial for the development and function of the nervous system. This process involves high rates of membrane expansion, during which the synthesis of membrane lipids must be tightly ...
Activation of peroxisome proliferator nuclear receptors regulates lipid metabolism in the placenta
(Galenos Yayincilik, 2007-09)
OBJECTIVE: Peroxisome proliferator activated receptors (PPARs), known regulators of lipid homeostasis in different tissues, are crucial during placental development. In this work we aim to determine whether PPARs activation ...
Dietary fat saturation produces lipid modifications in peritoneal macrophages of mouse
(Elsevier Science Inc, 2003-07)
We investigated the effects of a saturated fat diet on mice lipid metabolism in resident peritoneal macrophages. Male C57BL/6 mice were weaned at 21 days of age and assigned to either the experimental diet, containing ...
Peroxisome proliferator-activated receptor α activation regulates lipid metabolism in the feto-placental unit from diabetic rats
(BioScientifica, 2008-07)
Maternal diabetes promotes an overaccumulation of lipids in the feto-placental unit and impairs feto-placental development and growth. Here, we investigated the role played by the nuclear receptor peroxisome proliferator-activated ...
TAG synthesis and storage under osmotic stress. A requirement for preserving membrane homeostasis in renal cells
(Elsevier Science, 2018-09-14)
Hyperosmolarity is a controversial signal for renal cells. It can induce cell stress or differentiation and both require an active lipid metabolism. We showed that hyperosmolarity upregulates phospholipid (PL) de novo ...
FABP1 knockdown in human enterocytes impairs proliferation and alters lipid metabolism
(Elsevier Science, 2017-12)
Fatty Acid-Binding Proteins (FABPs) are abundant intracellular proteins that bind long chain fatty acids (FA) and have been related with inmunometabolic diseases. Intestinal epithelial cells express two isoforms of FABPs: ...
The inhibition of microtubule dynamics instability alters lipid homeostasis in TM4 Sertoli cells
(Academic Press Inc Elsevier Science, 2021-09-02)
Sertoli cells (SC) structurally support and transport nutrients to germ cells during spermatogenesis facilitated by an active cytoskeleton. Chemical perturbation of SC microtubule (MT) dynamics instability leads to premature ...
Sex-dependent changes in lipid metabolism, PPAR pathways and microRNAs that target PPARs in the fetal liver of rats with gestational diabetes
(Elsevier Ireland, 2018-02)
Gestational diabetes mellitus (GDM) is a prevalent disease that impairs fetal metabolism and development. We have previously characterized a rat model of GDM induced by developmental programming. Here, we analyzed lipid ...
Lipid metabolism alterations in the neuronal response to A53T α-synuclein and Fe-induced injury
(Elsevier Science Inc, 2018-10-08)
Pathological α-synuclein (α-syn) overexpression and iron (Fe)-induced oxidative stress (OS) are involved in the death of dopaminergic neurons in Parkinson's disease (PD). We have previously characterized the role of ...