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Purinergic Signaling Controls Spontaneous Activity in the Auditory System throughout Early Development
(Society for Neuroscience, 2021-01)
Spontaneous bursts of electrical activity in the developing auditory system arise within the cochlea before hearing onset and propagate through future sound-processing circuits of the brain to promote maturation of auditory ...
Virulence of Leuconostoc phages: Influence of stress conditions associated to dairy processes on their host-phage interactions
(Elsevier Science, 2019-05)
In this work, we assessed the impact of technological cell stress conditions, commonly present in industrial dairyprocesses, on the host strain-phage interactions in Leuconostoc. Adsorption and burst size of LDG ...
In vitro characterization of new stabilizing albumin nanoparticles as a potential topical drug delivery system in the treatment of corneal neovascularization (CNV)
(Editions Sante, 2019-08)
The aim of this work was to study the preparation process and the in vitro release of human serum albumin nanoparticles stabilized by Gantrez® ES-425, which was loaded with antiangiogenic drugs (suramin and bevacizumab). ...
Smart lipid nanoparticles containing levofloxacin and DNase for lung delivery. Design and characterization
(Elsevier Science, 2016-03)
Levofloxacin (LV) is a hydrophilic broad-spectrum antibiotic commonly used in pulmonary treatment against recurrent infections of Pseudomonas aeruginosa, and particularly in cystic fibrosis (CF) disease. In order to study ...
Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca2+ release events in a rodent model of early stage diabetes: The arrhythmogenic substrate
(Elsevier Ireland, 2016-01)
Background: Heart failure and arrhythmias occur more frequently in patients with type 2 diabetes (T2DM) than in the general population. T2DM is preceded by a prediabetic condition marked by elevated reactive oxygen species ...
New insights into the functional roles of reactive oxygen species during embryo sac development and fertilization in Arabidopsis thaliana
(Taylor & Francis, 2013-10)
Previously considered as toxic by-products of aerobic metabolism, reactive oxygen species (ROS) are emerging as essential signaling molecules in eukaryotes. Recent evidence showed that maintenance of ROS homeostasis during ...
Chitosan/hydroxyapatite composite bone tissue engineering scaffolds with dual and decoupled therapeutic ion delivery: Copper and strontium
(Royal Society of Chemistry, 2019-07)
Therapeutic metal ions are a family of metal ions characterized by specific biological properties that could be exploited in bone tissue engineering, avoiding the use of expensive and potentially problematic growth factors ...
Antibacterial mesoporous titania films with embedded gentamicin and surface modified with bone morphogenetic protein 2 to promote osseointegration in bone implants
(John Wiley & Sons Ltd, 2019-05-09)
Novel approaches are needed to avoid bacterial infections following implant surgery. Here the use of mesoporous titania films (MTFs) for gentamicin loading and delivery and the surface functionalization of MFTs with human ...
HMDSO-plasma coated electrospun fibers of poly(cyclodextrin)s for antifungal dressings
(Elsevier Science, 2016-11)
Electrospun mats containing cyclodextrin polymers (poly-αCD or poly-βCD) were developed to act as wound dressings showing tunable release rate of the antifungal agent fluconazole incorporated forming inclusion complexes. ...
A reanalysis of Nivaĉle k͡l and ɬ: phonetic, phonological and typological evidence
(University of Chicago Press, 2019-01)
This paper describes and analyzes the typologically unique lateral system of Nivaĉle (Mataguayan). There is no lateral approximant in this language, but rather two lateral obstruents: the lateral fricative /ɬ/ and the ...