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Topical vaccination with super-stable ready to use nanovesicles
(Elsevier Science, 2017-04)
Ultradeformable archaeosomes (UDA) are nanovesicles made of total polar archaeolipids (TPA) from the archaea Halorubrum tebenquichense, soybean phosphatidylcholine and sodium cholate (3:3:1 w/w). Fresh dispersions of UDA ...
Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer
(Springer, 2015-10)
Electroporation is a platform technology for drug and gene delivery. When applied to cell in vitro or tissues in vivo, it leads to an increase in membrane permeability for molecules which otherwise cannot enter the cell ...
Toll like receptors agonists-based nanomedicines as veterinary immunotherapies
(Andover House, 2020-06)
Many infections affecting animals enter across mucosa, needing of secretory immunity to reject the disease; protection against some pathogens must be early, fast, and specifically elicited, while from others must be wide ...
Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis
(Elsevier Ireland, 2006-06)
Experimental autoimmune orchitis (EAO) is an organ-specific model of autoimmunity characterized by an interstitial lymphomononuclear cell infiltrate as well as sloughing and apoptosis of germ cells. EAO was induced in adult ...
The polymeric antigen BLSOmp31 confers protection against Brucella ovis infection in rams
(Elsevier, 2009-11)
We have engineered the polymeric vaccine BLSOmp31 by decorating the highly immunogenic and decameric Brucella lumazine synthase with an exposed loop of the Brucella outer membrane protein Omp31. In the present study, we ...
Involvement of alpha2 and beta2-adrenoceptors on breast cancer cell proliferation and tumour growth regulation
(wiley, 2012-04-13)
Background and purpose: Beta-adrenoceptor (B-AR) expression is known in human and experimental animal breast cancer cells. However, the effect of the agonists and antagonists reported on cell proliferation and tumour growth ...
Influence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines
(Elsevier, 2014-11)
Immunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred ...
Charged particle spectrometry to measure 10B concentration in bone
(Springer, 2019-01-28)
Osteosarcoma is the most common primary malignant tumour of bone in young patients. The survival of these patients has largely been improved due to adjuvant and neo-adjuvant chemotherapy in addition to surgery. Boron neutron ...
Novel imiquimod nanovesicles for topical vaccination
(Elsevier Science, 2019-02)
Development of needle and pain free noninvasive immunization procedures is a top priority for public health agencies. In this work the topical adjuvant activity of the immunomodulator imiquimod (IMQ) carried by ultradeformable ...
Sublingual Omp16-driven redirection of the allergic intestinal response in a pre-clinical model of food allergy
(Wiley Blackwell Publishing, Inc, 2020-08)
Background: IgE-mediated food allergy remains a significant and growing worldwide problem. Sublingual immunotherapy (SLIT) shows an excellent safety profile for food allergy, but the clinical efficacy needs to be improved. ...