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Dissecting the Immune Stimulation Promoted by CSF-470 Vaccine Plus Adjuvants in Cutaneous Melanoma Patients: Long Term Antitumor Immunity and Short Term Release of Acute Inflammatory Reactants
(Frontiers Research Foundation, 2018-11)
As cutaneous melanoma (CM) currently remains with a bleak prognosis, thorough investigation of new treatment options are of utmost relevance. In the phase II/III randomized clinical trial (CASVAC-0401), the repeated ...
Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection
(Nature Publishing Group, 2017-02)
The parasite Trypanosoma cruzi is the causative agent of Chagas disease, a potentially life-threatening infection that represents a major health problem in Latin America. Several characteristics of this protozoan contribute ...
Combination of suicide and cytokine gene therapies as surgery adjuvant for canine mammary carcinoma
(MDPI, 2018-09)
The incidence of canine mammary carcinoma varies with age, breed, and spay status, being among the main tumors appearing in intact female dogs. Thirty-six canine mammary carcinoma patients received injections of canine ...
Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines
(Multidisciplinary Digital Publishing Institute, 2021-03-26)
The most important characteristics regarding the mucosal infection and immune responses against the Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) as well as the current vaccines against coronavirus disease 2019 ...
Beneficial effect of a mixture of vitamin-producing and immune-modulating lactic acid bacteria as adjuvant for therapy in a recurrent mouse colitis model
(Springer, 2019-11)
Inflammatory bowel diseases are chronic and relapsing-remitting disorders that affect the gastrointestinal tract. Previously, the administration of folate and riboflavin-producing lactic acid bacteria (LAB) or an ...
Immune response and functional role of antibodies raised in heifers against a Staphylococcus aureus CP5 lysate and recombinant antigens vaccine formulated with Iscom Matrix adjuvant
(2014-12-15)
Staphylococcus aureus is the most frequently isolated pathogen from bovine intramammary infections worldwide. Commercially available vaccines for mastitis control are composed either of S. aureus lysates or inactivated ...
Bacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment
(Elsevier Science, 2018-10)
The use of hybrid materials, where a matrix sustains nanoparticles controlling the release of the chemotherapeutic drug, could be beneficial for the treatment of primary tumors prior or after surgery. This localized ...
Non-clinical safety studies of IMT504, a unique non-CpG oligonucleotide
(Oxford University Press, 2014-05)
El IMTE 504 es un oligonucleotido de la linea no CgG, el cual estimula diferentes celulas del sistema inmune. El IMT 504 ha sido testeado en diferentes especies animales: raton, conejo, monos y su actividad fue efectiva ...
Development and therapeutic potential of vasopressin synthetic analog [V4Q5]dDAVP as a novel anticancer agent
(Elsevier Academic Press Inc., 2020-01)
Since its discovery, arginine vasopressin (AVP) was subjected to several modifications with the aim of obtaining novel derivatives with increased potency and selectivity for biomedical use. Desmopressin (dDAVP) is a first ...
A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses
(Elsevier Science, 2015-12)
We report here that a bacterial protease inhibitor from Brucella spp. called U-Omp19 behaves as an ideal constituent for a vaccine formulation against infectious diseases. When co-administered orally with an antigen (Ag), ...