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Recent clinical trials of cancer immunogene therapy in companion animals
(Baishideng Publishing Group, 2017-05)
This mini-review presents the results of veterinary clinical trials on immunogene therapy published from 2014 to 2016. A variety of tumors, among them melanoma(canine and equine), mastocytoma (canine), mammary adenocarcinoma ...
A new adenovector system for implementing thymulin gene therapy for inflammatory disorders
(Pergamon-Elsevier Science Ltd, 2017-07)
Thymulin is a thymic peptide possessing anti-inflammatory effects. In order to manipulate thymulin expression in gene therapy studies, we built a bidirectional regulatable two-vector Tet-Off system and the corresponding ...
Tumour cells resistant to ALA- mediated Photodynamic Therapy and possible tools to target
(Spandidos Publications, 2006-12)
We isolated and characterized cell lines resistant to aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) derived from a murine adenocarcinoma and studied cross resistance with other injuries. The most resistant ...
Beneficial effect of a mixture of vitamin-producing and immune-modulating lactic acid bacteria as adjuvant for therapy in a recurrent mouse colitis model
(Springer, 2019-11)
Inflammatory bowel diseases are chronic and relapsing-remitting disorders that affect the gastrointestinal tract. Previously, the administration of folate and riboflavin-producing lactic acid bacteria (LAB) or an ...
Temozolomide Does Not Impair Gene Therapy-Mediated Antitumor Immunity In Syngeneic Brain Tumor Models
(American Association For Cancer Research, 2014)
PURPOSE: Glioblastoma multiforme is the most common primary brain cancer in adults. Chemotherapy with temozolomide (TMZ) significantly prolongs the survival of patients with glioblastoma multiforme. However, the three-year ...
Intracerebroventricular delivery of human umbilical cord mesenchymal stem cells as a promising therapy for repairing the spinal cord injury induced by kainic acid
(Springer, 2020-02)
Spinal cord injury (SCI) is a common pathological condition that leads to permanent or temporal loss of motor and autonomic functions. Kainic acid (KA), an agonist of kainate receptors, a type of ionotropic glutamate ...
Crosstalk between ROS-dependent apoptotic and autophagic signaling pathways in Zn(II) phthalocyanine photodynamic therapy of melanoma
(Elsevier Science Inc, 2020-01-01)
Melanoma is the most aggressive type of skin cancer, highly resistant to conventional therapies. Photodynamic therapy (PDT) is a minimally invasive treatment modality that combines the use of a photosensitizer, visible ...
Cytokine-Enhanced Vaccine and Interferon-β plus Suicide Gene Therapy as Surgery Adjuvant Treatments for Spontaneous Canine Melanoma
(Mary Ann Liebert Inc, 2015-03)
We present here a nonviral immunogene therapy trial for canine malignant melanoma, an aggressive disease displaying significant clinical and histopathological overlapping with human melanoma. As a surgery adjuvant approach, ...
Natural photosensitizers in photodynamic therapy: In vitro activity against monolayers and spheroids of human colorectal adenocarcinoma SW480 cells
(Elsevier Science, 2020-09)
Photodynamic Therapy (PDT), is a treatment option for cancer.It involves the photochemical interaction of light, photosensitizer (PS) and molecular oxygen to produce radical species as well as singlet oxygen which induce ...
Photodynamic therapy in fibrosarcoma BALB/c animal model: Observation of the rebound effect
(Elsevier Science, 2018-03)
In vivo spectrofluorometric analysis during photodynamic therapy (PDT) is a fundamental tool to obtain information about drug bleaching kinetics. Using a portable spectrofluorometer with an excitation source emitting at ...