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mPEG–NHS carbonates: Effect of alkyl spacers on the reactivity: Kinetic and mechanistic insights
(John Wiley & Sons Inc, 2019-02)
Nowadays, the chemical conjugation to mPEG, also known as PEGylation, is a well-recognized technology used to improve the pharmaceutical properties of the therapeutic proteins. Over the last 20 years, more than 10 PEGylated ...
High hydrostatic pressure- or heat-induced gelation of cowpea proteins at low protein content: Effect of calcium concentration
(Elsevier, 2022-03)
The effect of different calcium levels (10–40 mM) during protein denaturation on the characteristics of cowpea protein gels obtained by heating or high hydrostatic pressure treatment (HHPT) at low protein content (7.5%w/w) ...
Role of protein tyrosine phosphatase 1B (PTP1B) in the increased sensitivity of endothelial cells to a promigratory effect of erythropoietin in an inflammatory environment
(De Gruyter, 2020-07)
The proliferation and migration of endothelial cells are vascular events of inflammation, a process which can also potentiate the effects of promigratory factors. With the aim of investigating possible modifications in the ...
Inmuno-spin trapping from biochemistry to medicine: advances, challenges, and pitfalls. Focus on protein-centered radicals
(Elsevier Science, 2014-02)
Background: Immuno-spin trapping (IST) is based on the reaction of a spin trap with a free radical to form a stable nitrone adduct, followed by the use of antibodies, rather than traditional electron paramagnetic resonance ...
Novel reactive PEG for amino group conjugation
(Royal Society of Chemistry, 2015-01)
Activated mPEG carbonates are important reagents that have been widely used for the PEGylation of several peptides and proteins by means of stable urethane linkages. In fact, mPEG-N-hydroxysuccinimidyl carbonate and ...
Alcohol induction of liver nuclear ethanol and N-nitrosodimethylamine metabolism to reactive metabolites
(Wiley, 2002-01)
In previous studies from our laboratory we reported the presence in highly purified liver nuclei, free of contamination with other organelles, of an ethanol metabolizing system (NEMS) able to lead to acetaldehyde and ...
Immune-mediated inflammation promotes subclinical atherosclerosis in recent-onset psoriatic arthritis patients without conventional cardiovascular risk factors
(Frontiers Media S.A., 2018-02)
Studies on the inflammatory burden in recent-onset psoriatic arthritis (PsA) patients without conventional cardiovascular risk factors (CVRFs) are not available. This preliminary study focuses on cardiovascular risk in ...
Bovine plasma protein as an alternative protein source in extruded aquafeeds for Piaractus mesopotamicus (pacú) at two fattening stages
(Wiley Blackwell Publishing, Inc, 2019-11-20)
An 84‐day feeding trial was conducted to evaluate the addition of bovine plasma protein concentrate (BPP) as a full replacement of fish meal (FM) in extruded aquafeeds for the fish Piaractus mesopotamicus at two fattening ...
TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation
(Elsevier, 2018-03)
Objective: Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family. In this ...
Underestimation of mycobacterium tuberculosis infection in HIV-infected subjects using reactivity to tuberculin and anergy panel
(Oxford University Press, 2000-04)
Background. This study aimed to evaluate purified protein derivative (PPD) reactivity and its interrelationship with anergy panel and CD4+ lymphocytes in HIV-infected subjects as compared to PPD reactivity in HIV-uninfected ...