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Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes
(National Academy of Sciences, 2009-11)
Profiling the dynamic interaction of p300 with proximal promoters of human T cells identified a class of genes that rapidly coassemble p300 and RNA polymerase II (pol II) following mitogen stimulation. Several of these ...
Yersinia-triggered arthritis in IL-12p40-deficient mice: Relevant antigens and local expression of Toll-like receptor mRNA
(Taylor & Francis As, 2007-12)
To study the role of IL-12p40 at the onset of reactive arthritis (ReA) after Yersinia enterocolitica O:3 infection, and analyse relevant microbial antigens and articular expression of Toll-like receptor (TLR) mRNA. Methods: ...
Mesenchymal stem cell therapy improves spatial memory and hippocampal structure in aging rats
(Elsevier Science, 2019-11-18)
There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine in the brain as they have shown neurogenic and immunomodulatory activities. We assessed the effect of ...
Endometriosis progression in tumor necrosis factor receptor p55-deficient mice: Impact on oxidative/nitrosative stress and metallomic profile
(Elsevier Gmbh, 2019-03)
The present study was conducted to investigate whether the deficiency of tumor necrosis factor receptor p55 (TNFRp55) modulates oxidative/nitrosative stress and metallomic profile into the peritoneal cavity during the ...
Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
(ELSEVIER BV, 2016-04)
AbstractOxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration (AMD), a multifactorial disease that includes age, gene variants of complement regulatory proteins and smoking as the ...
The Nitrone Spin Trap 5,5-Dimethyl-1-pyrroline N-oxide prevents M1-like Phenotypic Switch of Lipopolysaccharide-Primed Macrophages
(Pharmaceutical and Chemical Journal, 2018-06)
M1-like inflammatory phenotype of macrophages plays a critical role in tissue damage in chronic inflammatory diseases. M1-like macrophages produce reactive oxygen species, inflammatory cytokines (IL-1b, IFNb), express ...
The Pseudomonas aeruginosa biofilm matrix and cells are drastically impacted by gas discharge plasma treatment: A comprehensive model explaining plasma-mediated biofilm eradication
(Public Library of Science, 2019-06)
Biofilms are microbial communities encased in a protective matrix composed of exopolymeric substances including exopolysaccharides, proteins, lipids, and extracellular DNA. Biofilms cause undesirable effects such as ...
Heme Oxygenase 1 Impairs Glucocorticoid Receptor Activity in Prostate Cancer
(Molecular Diversity Preservation International, 2019-02)
Glucocorticoids are used during prostate cancer (PCa) treatment. However, they may also have the potential to drive castration resistant prostate cancer (CRPC) growth via the glucocorticoid receptor (GR). Given the association ...
Association of HO-1 and BRCA1 is critical for the maintenance of cellular homeostasis in prostate cancer
(American Association for Cancer Research, 2015-11)
Prostate cancer is the second leading cause of cancer-related death in men worldwide. Many factors that participate in the development of prostate cancer promote imbalance in the redox state of the cell. Accumulation of ...
Estudio proteómico para mejorar el reactivo PPD-B utilizado en el diagnóstico de tuberculosis bovina: Producción de nuevas mezclas enriquecidas con los componentes más antigénicos de la PPD-BProteomic study to improve PPD-B reagent used in the diagnosis of bovine tuberculosis: Production of new mixtures enriched with PPD-B antigenic components
(Asociación Argentina de Zoonosis, 2015-12)
La reacción de hipersensibilidad retardada (DTH) producida por la aplicación intradérmica del derivado proteico purificado de una cepa de M. bovis (PPD-B) y la prueba que mide liberación de interferón-gamma (IFN-ϒ) son ...