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Gene therapy for brain tumors: Basic developments and clinical implementation
(Elsevier Ireland, 2012-10)
Glioblastoma multiforme (GBM) is the most common and deadliest of adult primary brain tumors. Due to its invasive nature and sensitive location, complete resection remains virtually impossible. The resistance of GBM against ...
Human α-galactosidase a mutants: Priceless tools to develop novel therapies for fabry disease
(MDPI AG, 2021-06)
Fabry disease (FD) is a lysosomal storage disease caused by mutations in the gene for the α-galactosidase A (GLA) enzyme. The absence of the enzyme or its activity results in the accumulation of glycosphingolipids, mainly ...
Current phthalocyanines delivery systems in photodynamic therapy: An updated review
(Bentham Science Publishers, 2021-02)
Photodynamic therapy has emerged as an effective therapeutic alternative to treat oncological, cardiovascular, dermatological, infectious, and ophthalmic diseases. Photodynamic therapy combines the action of a photosensitizer ...
Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity
(Baishideng Publishing Group, 2014-12)
Photodynamic therapy is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with specific light activation of a photosensitizer agent. Whereas interstitial and intra-operative ...
Igf-1 gene therapy as a potentially useful therapy for spontaneous prolactinomas in senile rats
(Bentham Science Publishers, 2018-08)
Background: Insulin-like Growth Factor1 (IGF1) is a powerful neuroprotective molecule. We have previously shown that short-term hypothalamic IGF1 gene therapy restores tuberoinfundibu-lar dopaminergic neuron function in ...
Clinical and molecular study of a case of severe radio-sensitivity
(MedCrave, 2019-12)
A case of a patient with a breast intraductal tumor is presented. The patient underwent surgical quadrantectomy and axillary lymph node dissection and subsequently received Anthracycline treatment and 3D radiotherapy ...
Cell therapy for Parkinson′s disease is coming of age: current challenges and future prospects with a focus on immunomodulation
(Nature Publishing Group, 2020-02)
Parkinson's disease (PD) is a neurodegenerative disease that affects more than 1% of people over the age of 60. The principal feature of this disease is the progressive loss of dopaminergic neurons (DAn) within the ...
Stem cells and COVID-19: are the human amniotic cells a new hope for therapies against the SARS-CoV-2 virus?
(Springer, 2021-03)
A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing social, economic, and health problems. The COVID-19 triggers a lung infection with a multiple proinflammatory ...
Pyrrhonian Argumentation: Therapy, Dialectic, and Inquiry
(De Gruyter, 2020-04)
The Pyrrhonist's argumentative practice is characterized by at least four features. First, he makes a therapeutic use of arguments: He employs arguments that differ in their persuasiveness in order to cure his dogmatic ...
Oxidative Stress in Muscle Diseases: Current and Future Therapy
(Landes Bioscience, 2018-04)
Oxidative stress can be considered a consequence ofimbalance in the formation of reactive oxygen species(ROS) and antioxidant defense systems, in which mitochondriaappear to be the main source of ROS production. A keyconcern ...