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Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review
(Elsevier Science, 2019-10)
Neglected tropical diseases (NTDs) constitute a group of infectious diseases prevalent in countries with tropical and subtropical climate that affect the poorest individuals and produce high chronic disability associated ...
Effects of natural antioxidants in neurodegenerative disease
(Maney Publishing, 2012-01)
Polyphenols are secondary metabolites with antioxidant properties and are abundant in the diet. Fruits, vegetables, herbs, and various drinks (tea, wine, and juices) are all sources of these molecules. Despite their ...
Coeliac disease pathogenesis: The uncertainties of a well-known immune mediated disorder
(Frontiers Media, 2020-07-08)
Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive ...
Polymeric micelles and nanomedicines: Shaping the future of next generation therapeutic strategies for infectious diseases
(Editions Sante, 2021-12)
Despite all the advances in understanding the pathogenesis of infectious diseases and the development of novel treatments to combat them, these pathogenic disorders are among the most common reasons for hospitalizations ...
Chagas disease vaccine design: the search for an efficient Trypanosoma cruzi immune-mediated control
(Elsevier Science, 2020-05)
Chagas disease is currently endemic to 21 Latin-American countries and has also become a global concern because of globalization and mass migration of chronically infected individuals. Prophylactic and therapeutic vaccination ...
Uncovering disease mechanisms through network biology in the era of Next Generation Sequencing
(Nature Publishing Group, 2016-04)
Characterizing the behavior of disease genes in the context of biological networks has the potential to shed light on disease mechanisms, and to reveal both new candidate disease genes and therapeutic targets. Previous ...
Review article: Shared disease mechanisms between non-alcoholic fatty liver disease and metabolic syndrome – translating knowledge from systems biology to the bedside
(Wiley Blackwell Publishing, Inc, 2019-03)
Background/Aim: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. Characterised by abnormal fat accumulation in the liver, NAFLD presents high degree of comorbidity with ...
Circulating MicroRNA-122 signature in nonalcoholic fatty liver disease and cardiovascular disease: A new endocrine system in metabolic syndrome
(John Wiley & Sons Inc, 2013-06)
To the Editor: We read with great interest the article by Bala et al. about the role of circulating microRNAs (miRNAs) as markers of alcohol‐ and acetaminophen‐induced liver damage in a mouse model; the investigators ...
Impact of migration on the occurrence of new cases of Chagas disease in Buenos Aires city, Argentina
(Open Learning on Enteric Pathogens, 2013-08)
Chagas disease, also known as American Trypanosomiasis, is endemic in the Americas, especially Central and South America. Chagas disease is a zoonotic disease caused by the parasite Trypanosoma cruzi. Most of the infections ...
Influence of Vectors' Risk-Spreading Strategies and Environmental Stochasticity on the Epidemiology and Evolution of Vector-Borne Diseases: The Example of Chagas' Disease
(Public Library of Science, 2013-08)
Insects are known to display strategies that spread the risk of encountering unfavorable conditions, thereby decreasing the extinction probability of genetic lineages in unpredictable environments. To what extent these ...