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Limited diagnostic usefulness of antibodies to cytoplasmic proteins of Brucella in early-treated human brucellosis.
(Taylor & Francis As, 2001-12)
Antibodies to cytoplasmic proteins (CP) of Brucella have been shown to be useful for the diagnosis of human brucellosis; however, some early-diagnosed patients lack such an antibody response while having high titers of ...
In Silico Insight into the Reductive Nitrosylation of Ferric Hemeproteins
(American Chemical Society, 2020-03)
A combination of in silico methods was used to extend the 5 experimental description of the reductive nitrosylation mechanism in ferric 6 hemeproteins with the molecular details of the role of surrounding amino acids. 7 ...
Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: An innovative concept for smart nanotheranostics
(Royal Society of Chemistry, 2021-04)
After several decades of development in the field of near-infrared (NIR) dyes for photothermal therapy (PTT), indocyanine green (ICG) still remains the only FDA-approved NIR contrast agent. However, upon NIR light irradiation ...
Presynaptic inhibition of spontaneous acetylcholine release mediated by P2Y receptors at the mouse neuromuscular junction
(Pergamon-Elsevier Science Ltd, 2006-09)
At the neuromuscular junction, ATP is co-released with the neurotransmitter acetylcholine (ACh) and once in the synaptic space, it is degraded to the presynaptically active metabolite adenosine. Intracellular recordings ...
The cardiac electrogenic sodium/bicarbonate cotransporter (NBCe1) is activated by aldosterone through the G protein-coupled receptor 30 (GPR 30)
(Landes Bioscience, 2016-09)
The sodium/bicarbonate cotransporter (NBC) transports extracellular Na+ and HCO3 − into the cytoplasm upon intracellular acidosis, restoring the acidic pHi to near neutral values. Two different NBC isoforms have been ...
Hypertension and Insulin Resistance: Implications of Mitochondrial Dysfunction
(Springer, 2014-11)
Mitochondria are the primary generators of cellular reactive oxygen species (ROS); their pathophysiological roles in hypertension and insulin resistance are but imperfectly understood. Mitochondrial dysfunction has been ...
Cardiac-oxidized antigens are targets of immune recognition by antibodies and potential molecular determinants in chagas disease pathogenesis
(Public Library of Science, 2012-01)
Trypanosoma cruzi elicits reactive oxygen species (ROS) of inflammatory and mitochondrial origin in infected hosts. In this study, we examined ROS-induced oxidative modifications in the heart and determined whether the ...
Time course changes of oxidative stress markers in a rat experimental glaucoma model
(Association for Research in Vision and Ophthalmology, 2010-09)
PURPOSE. To evaluate the relationship between oxidative stress arkers and increased intraocular pressure in experimental laucoma. METHODS. In vivo chemiluminescence (CL), total antioxidant apacity (TRAP), nitrite concentration ...
High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice
(Molecular Diversity Preservation International, 2018-02-10)
Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, ...
Increased resistance to hydrogen peroxide-induced cardiac contracture is associated with decreased myocardial oxidative stress in hypothyroid rats
(John Wiley & Sons Ltd, 2010-01)
The purpose of this study was to determine whether decreased oxidative stress would increase the resistance to cardiac contracture induced by H 2O2 in hypothyroid rats. Male Wistar rats were divided into two groups: control ...