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Measurement of malondialdehyde as oxidative stress biomarker in goat plasma by HPLC-DAD
(Elsevier Science, 2016-11)
During the cattle breeding, the animals are exposed to stressful conditions (confinement, competition, extreme temperatures, pathogens); these have been associated to the increase of reactive oxygen species that attack ...
Systematic screening for novel, serologically reactive Hepatitis e Virus epitopes
(BioMed Central, 2012-01)
Background: The National Institutes of Health classified Hepatitis E as an emerging disease since Hepatitis E Virus (HEV) is the major cause of acute hepatitis in developing countries. Interestingly, an increasing number ...
Coordination of peroxide to the CuM center of peptidylglycine α-hydroxylating monooxygenase (PHM): Structural and computational study
(Springer, 2013-02)
Many bioactive peptides, such as hormones and neuropeptides, require amidation at the C terminus for their full biological activity. Peptidylglycine a-hydroxylating monooxygenase (PHM) performs the first step of the amidation ...
Inhibition of Lipid Oxidation by MRP Antioxidant in Enriched Cooked Beef Patties with Polyunsaturated Fatty Acids
(Canadian Center of Science and Education, 2012-07-02)
The addition of n3 polyunsaturated fatty acids to foods is an emerging area of commercial and academic interest. However, the incorporation of n3 polyunsaturated fatty acids into food systems is potentially problematic ...
Hypoxia-ischemia alters distribution of lysosomal proteins in rat cortex and hippocampus
(Company of Biologists, 2018-10-25)
Neuronal excitotoxicity induced by glutamatergic receptor overstimulation contributes to brain damage. Recent studies have shown that lysosomal membrane permeabilization (LMP) is involved in ischemia-associated neuronal ...
Modulation of microglia and presynaptic protein expression after mesenchymal stem cells treatment in a rat model of Alzheimer's disease
(Elsevier, 2019-09)
Objectives: Sporadic Alzheimer´s disease (sAD) is the most prevalent neurodegenerative pathology with no effective therapy until date. This disease prompts hippocampal degeneration, which in turn affects multiple cognitive ...
Nitroxyl (azanone) trapping by metalloporphyrins
(Elsevier Science Sa, 2011-12)
The present review starts describing nitroxyl (azanone, 1HNO) biological relevance, in relation with NO physiology, from a chemical reactivity perspective. After a description of commonly used azanone donors and their ...
Structural and functional complexity of the humoral response against the Trypanosoma cruzi ribosomal P2β protein in patients with chronic Chagas' heart disease
(Wiley Blackwell Publishing, Inc, 2004-06)
High levels of antibodies against the C-terminus of the Trypanosoma cruzi TcP2β ribosomal protein, defined by the peptide EEEDDDMGFGLFD, named R13, have been measured in sera from patients with chronic Chagas' Heart Disease ...
A computational investigation of the reactions of tyrosyl, tryptophanyl, and cysteinyl radicals with nitric oxide and molecular oxygen
(Taylor & Francis Ltd, 2019-01)
Proteins are main targets of oxidants in biological systems. This oxidation may occur in the protein backbone as well as in certain amino acid side chains, depending on the oxidant and amino acid intrinsic reactivity. ...
The effect of Midazolam and Propranolol on fear memory reconsolidation in ethanol-withdrawn rats: Influence of D-cycloserine
(Oxford University Press, 2014-01)
Background: Withdrawal from chronic ethanol facilitates the formation of contextual fear memory and delays the onset to extinction, with its retrieval promoting an increase in ethanol consumption. Consequently, manipulations ...