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Interpersonal clarification effects in Cognitive-Behavioral Therapy for depression and how they are moderated by the therapeutic alliance
(Elsevier Science, 2021-01)
Background: Although a wide body of research links depression to interpersonal deficits, Cognitive-Behavioral Therapy (CBT), considered the gold standard in the treatment of this condition, has not been developed to ...
Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas
(Oxford University Press, 2013-05)
Background: Metronomic chemotherapy (MCT) refers to the chronic and equally spaced administration of low doses of different chemotherapy drugs, without extended rest periods. Herein, we investigated the therapeutic efficacy ...
Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
(Multidisciplinary Digital Publishing Institute, 2021-06)
The use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide stricter, focused, and fine-tuned therapy, enhancing the therapeutic ...
Dually responsive nanogels as smart carriers for improving the therapeutic index of doxorubicin for breast cancer
(Pergamon-Elsevier Science Ltd, 2019-07)
Nanocarriers can significantly improve the therapeutic index of drug in cancer therapy. At present, parenteral administration of free doxorubicin (Dox) to treat breast tumor produces severe side effects including cardiotoxicity. ...
Taking advantage of the potential of mesenchymal stromal cells in liver regeneration: Cells and extracellular vesicles as therapeutic strategies
(W J G Press, 2018-06)
Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells (MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing ...
A special issue on nanomedicine in Latin America
(American Scientific Publisher, 2013-02-01)
This special issue of Journal of Biomaterials and Tissue Engineering includes articles from Latin American researchers that work in an emerging discipline at the interface of biomaterials science, nanotechnology and ...
A nanocrystal-based formulation improves the pharmacokinetic performance and therapeutic response of albendazole in dogs
(Pharmaceutical Press-Royal Pharmaceutical Society Great Britian, 2018-01-16)
We aimed to assess the pharmacokinetic performance and therapeutic response (anthelmintic efficacy) of an albendazole (ABZ) nano-sized formulation in dogs. Methods: In the pharmacokinetic study, ABZ self-dispersible ...
Can dermal delivery of therapeutics be improved using thermoresponsive nanogels?
(Future Medicine, 2019-11)
Skin, being the largest organ of the body, has attracted a lot of attention in recent years as a vector to deliver awide spectrum of cargo molecules to treat multiple conditions, including genetic disorders, infections by ...
Minthostachys verticillata essentials oil and its major components: antiherpetic selective action in HEp-2 cells
(Instituto de Investigación de las Ciencias Exactas Físicas y Naturales, 2010-01)
The medicinal herb Minthostachys verticillata was studied in various fields of natural medicine. Numerous studies were made to evaluate its antimicrobial properties. This work emphasizes in the analysis of the antiviral ...
Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity
(Baishideng Publishing Group, 2014-12)
Photodynamic therapy is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with specific light activation of a photosensitizer agent. Whereas interstitial and intra-operative ...