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Structural Impact of Mutation D614G in SARS-CoV-2 Spike Protein: Enhanced Infectivity and Therapeutic Opportunity
(American Chemical Society, 2020-09)
With the COVID-19 pandemic, the evolutionary fate of SARS-CoV-2 becomes a matter of utmost concern. Mutation D614G in the spike (S) protein has become dominant, and recent evidence suggests it yields a more stable phenotype ...
Highlighting the interplay of microRNAs from Leishmania parasites and infected-host cells
(Cambridge University Press, 2021-07)
Leishmania parasites, the causative agents of leishmaniasis, are protozoan parasites with the ability to modify the signaling pathway and cell responses of their infected host cells. These parasite strategies alter the ...
Pathophysiological role of histamine H4 Receptor in cancer: therapeutic implications
(Frontiers Media S.A., 2019-05)
Cancer is a leading cause of death in both developed and developing countries. Although advances in cancer research lead to improved anti-neoplastic therapies, they continue to have unfavorable outcomes, including poor ...
Immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders
(John Wiley & Sons Inc., 2021-10)
Neurodegenerative diseases (NDD) are disorders characterized by the progressive loss of neurons affecting motor, sensory, and/or cognitive functions. The incidence of these diseases is increasing and has a great impact due ...
Effects of oral administration of silymarin in a juvenile murine model of non-alcoholic steatohepatitis
(Molecular Diversity Preservation International, 2017-09)
The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in adolescents is challenging the global care system. No therapeutic strategies have been defined so far, and changes in the lifestyle remain the only ...
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
(Taylor & Francis, 2014-03)
The most neglected aspects of Chagas disease (CD) have been patient care and treatment. Despite recent progress in the development of potentially improved drugs, there is no consensus among different research groups on the ...
In vivo bactericidal efficacy of gwh1 antimicrobial peptide displayed on protein nanoparticles, a potential alternative to antibiotics
(MDPI AG, 2020-12)
Oligomerization of antimicrobial peptides into nanosized supramolecular complexes produced in biological systems (inclusion bodies and self-assembling nanoparticles) seems an appealing alternative to conventional antibiotics. ...
Methods to Investigate Signal Transduction Pathways in Trypanosoma cruzi: Cyclic Nucleotide Phosphodiesterases Assay Protocols
(Springer, 2020-03)
Intracellular levels of cyclic nucleotide second messengers are regulated predominantly by a large superfamily of phosphodiesterases (PDEs). Most of the different PDE variants play specific physiological functions; in fact, ...
Inflammation and insulin resistance as risk factors and potential therapeutic targets for Alzheimer’s disease
(Frontiers Media S.A., 2021-04)
Overnutrition and modern diets containing high proportions of saturated fat are among the major factors contributing to a low-grade state of inflammation, hyperglycemia and dyslipidemia. In the last decades, the global ...
Exploiting the therapeutic potential of ready-to-use drugs: Repurposing antibiotics against amyloid aggregation in neurodegenerative diseases
(Pergamon-Elsevier Science Ltd, 2018-03)
Neurodegenerative diseases are chronic and progressive disorders that affect specific regions of the brain, causing gradual disability and suffering that results in a complete inability of patients to perform daily functions. ...