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Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase
(Blackwell Publishing Ltd, 2000-01-01)
Infective forms of Trypanosoma cruzi, the parasite that causes Chagas' disease, express on their surface an enzyme denominated trans-sialidase (TS). the present study was designed to evaluate the naturally acquired immune ...
Pineal melatonin and the innate immune response: the TNF-alpha increase after cesarean section suppresses nocturnal melatonin production
(Blackwell Publishing, 2007-11-01)
The nocturnal surge of melatonin is the endocrine expression of the circadian system and is essential for organizing the timing of various endogenous processes. Previous works suggest that, in the beginning of a defense ...
Heterologous Plasmid DNA Prime-Recombinant Human Adenovirus 5 Boost Vaccination Generates a Stable Pool of Protective Long-Lived CD8(+) T Effector Memory Cells Specific for a Human Parasite, Trypanosoma cruzi
(Amer Soc Microbiology, 2011-05-01)
Recently, we described a heterologous prime-boost strategy using plasmid DNA followed by replication-defective human recombinant adenovirus type 5 as a powerful strategy to elicit long-lived CD8(+) T-cell-mediated protective ...
Inhibitory effect of the Pseudobrickellia brasiliensis (Spreng) RM King & H. Rob. aqueous extract on human lymphocyte proliferation and IFN-gamma and TNF-alpha production in vitro
(Assoc Bras Divulg Cientifica, 2017)
Pseudobrickellia brasiliensis (Asteraceae) is a plant commonly known as arnica-do-campo and belongs to the native flora of the Brazilian Cerrado. The alcoholic extract of the plant has been used as an anti-inflammatory ...
Prophylactic and Therapeutic Vaccination Using Dendritic Cells Primed with Peptide 10 Derived from the 43-Kilodalton Glycoprotein of Paracoccidioides brasiliensis
(Amer Soc Microbiology, 2012-01-01)
Vaccination with peptide 10 (P10), derived from the Paracoccidioides brasiliensis glycoprotein 43 (gp43), induces a Th1 response that protects mice in an intratracheal P. brasiliensis infection model. Combining P10 with ...
Enhanced natural killer activity and production of pro-inflammatory cytokines in mice selected for high acute inflammatory response (AIRmax)
(Blackwell Publishing, 2007-03-01)
Strains of mice with maximal and minimal acute inflammatory responsiveness (AIRmax and AIRmin, respectively) were developed through selective breeding based on their high- or low-acute inflammatory responsiveness. Previous ...
Quantification of bovine cytokine gene expression using real-time RT-PCR methodology
(Sociedade Brasileira de Genética, 2007-01-01)
T cells produce cytokines that affect host response to infection. This paper reports real-time RT-PCR conditions and validation steps for accurate quantification of Bos indicus cytokines, interleukin (IL)-2, IL-4, IL-8, ...
SUPPORT OF PARACOCCIDIOIDES-BRASILIENSIS MULTIPLICATION BY HUMAN MONOCYTES OR MACROPHAGES - INHIBITION BY ACTIVATED PHAGOCYTES
(Chapman Hall Ltd, 1994-03-01)
The interaction of human monocytes or monocyte-derived macrophages and yeast-form Paracoccidioides brasiliensis was studied in vitro. Yeast cells were readily ingested by adherent monocytes or macrophages. Multiplication ...
Influence of different doses of retinoic acid on cardiac remodeling
(Elsevier B.V., 2011-07-01)
Objective: The role of retinoic acid in promoting postnatal heart alterations is still unclear. The aim of this study was to evaluate whether the cardiac alterations caused by all-trans- retinoic acid (ATRA) in normal adult ...