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Effect of the bacillus of Calmette-Guerin, Propionibacterium acnes and avridine as immunomodulators in antirabies vaccination of mice using the Fuenzalida-Palacios mouse brain vaccine
(Elsevier B.V., 1999-05-14)
Using the laboratory mice, Fuenzalida-Palacios mouse brain human rabies vaccine was administered in groups of animals previously inoculated with rabies virus and then submitted to treatments with the immunomodulators ...
IFNG +874 T > A single nucleotide polymorphism is associated with leprosy among Brazilians
(Springer, 2010-11-01)
Leprosy is a chronic infectious disease caused by Mycobacterium leprae, a low virulence mycobacterium, and the outcome of disease is dependent on the host genetics for either susceptibility per se or severity. The IFNG ...
Predominance of CD4 Th1 and CD8 Tc1 cells revealed by characterization of the cellular immune response generated by immunization with a DNA vaccine containing a Trypanosoma cruzi gene
(Amer Soc Microbiology, 1999-08-01)
Immunization with a plasmid DNA containing the gene encoding the catalytic domain of trans-sialidase (TS) elicits protective immune responses against experimental Trypanosoma cruzi infection. As several studies provided ...
Acquired immune responses to the N- and C-terminal regions of Plasmodium vivax merozoite surface protein 1 in individuals exposed to malaria
(Amer Soc Microbiology, 1997-05-01)
In this study, we evaluated the naturally acquired immune response to Plasmodium vivax merozoite surface protein 1 (PvMSP1) in individuals with recent clinical episodes of malaria from the state of Para, Brazil. Ten ...
Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by 1-NAME in rats
(Pergamon-Elsevier B.V. Ltd, 2012-09-04)
Aims: Inhibition of nitric oxide synthase with N-omega-nitro-L-arginine methyl ester (L-NAME) has been employed as an experimental model of human preeclampsia. This study determined the protective effect of silibinin, a ...
Recombinant Yellow Fever Viruses Elicit CD8(+) T Cell Responses and Protective Immunity against Trypanosoma cruzi
(Public Library Science, 2013-03-19)
Chagas' disease is a major public health problem affecting nearly 10 million in Latin America. Despite several experimental vaccines have shown to be immunogenic and protective in mouse models, there is not a current vaccine ...
Infrared low-level diode laser on inflammatory process modulation in mice: pro- and anti-inflammatory cytokines
(Springer, 2013-09-01)
To evaluate the modulation of proinflammatory (interleukin-6, IL-6; tumor necrosis factor-alpha, TNF-alpha; and interferon-gamma, IFN-gamma) and anti-inflammatory cytokines (transforming growth factor-beta 1, TGF-beta 1) ...
Gene Therapy against Murine Melanoma B16F10-Nex2 Using IL-13R alpha 2-Fc Chimera and Interleukin 12 in Association with a Cyclopalladated Drug
(Neoplasia Press, 2008-09-01)
Interleukin 13 (IL-13) is immunoregulatory in many diseases, including cancer. the protective or suppressive role of CD1-restricted natural killer T cells (NKT cells) in tumor immunosurveillance and immunity is well ...
Chemically induced immunotoxicity in a medium-term multiorgan bioassay for carcinogenesis with Wistar rats
(Elsevier B.V., 2004-01-15)
A variety of chemicals can adversely affect the immune system and influence tumor development. The modifying potential of chemical carcinogens on the lymphoid organs and cytokine production of rats submitted to a medium-term ...