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Structures of human purine nucleoside phosphorylase complexed with inosine and ddI
(Elsevier B.V., 2004-01-23)
Human purine nucleoside phosphorylase (PNP) is a ubiquitous enzyme which plays a key role in the purine salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent ...
Structural bioinformatics study of cyclin-dependent kinases complexed with inhibitors
(Editora Unesp, 2003-01-01)
O presente trabalho descreve modelos moleculares para os complexos binários CDK9, CDK5 e CDK1 complexados com Flavopiridol e Roscovitina. Esses modelos estruturais indicam que os inibidores ligam-se fortemente ao sítio de ...
Structural Basis for Interaction of Inhibitors with Cyclin-Dependent Kinase 2
(Bentham Science Publ Ltd, 2005-01-01)
Cell cycle progression is tightly controlled by the activity of cyclin-dependent kinases (CDKs). CDKs are inactive as monomers, and activation requires binding to cyclins, a diverse family of proteins whose levels oscillate ...
Histochemical study of the extensor digitorum longus and soleus muscles in alcoholic rats
(Blackwell Wissenschafts Verlag Gmbh, 1999-12-01)
The extensor digitorum longus (EDL) and soleus (SOL) muscle fibres from albino rats submitted to experimental chronic alcoholism were evaluated in accordance with their metabolic and morphometric profiles. Twenty-seven ...
Morphological and histochemical analysis of the human vestibular fold
(2007-09-01)
A morphological and histochemical study of the human vestibular fold was carried out using routine histological techniques. Seven μm-thick histological sections stained with hematoxylin-eosin (HE) and Calleja showed the ...
Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome
(PLOS Neglected Tropical Diseases, 2018)
Association of NAD(P)H Oxidase with Glucose-Induced Insulin Secretion by Pancreatic beta-Cells
(Endocrine Soc, 2009-05-01)
We previously described the presence of nicotinamide adenine dinucleotide phosphate reduced form [NAD(P)H] oxidase components in pancreatic beta-cells and its activation by glucose, palmitic acid, and proinflammatory ...
Deletion of 17p13 and LIS1 gene mutation in isolated lissencephaly sequence
(Elsevier B.V., 2006-07-01)
Classical lissencephaly is a neuroblast migration disorder that occurs either as isolated lissencephaly sequence or in association with malformation syndromes, such as the Miller-Dieker syndrome. in this work, alterations ...
HNA-3 gene frequencies in Brazilians and a new polymerase chain reaction-restriction fragment length polymorphism method for HNA-3a/3b genotyping
(Wiley-Blackwell, 2014-06-01)
Background HNA-3 antigens are the result of a rs2288904 single-nucleotide polymorphism (SNP) in the CTL2, and the HNA-3a and HNA-3b variants are encoded by a guanine and adenine at Nucleotide Position 461. Anti-HNA-3 are ...
Effects of nandrolone decanoate on the neuromuscular junction of rats submitted to swimming
(Elsevier B.V., 2004-12-01)
This study addressed the effects of nandrolone decanoate (ND) on contractile properties and muscle fiber characteristics of rats submitted to swimming. Male Wistar rats were grouped in sedentary (S), swimming (Sw), ...