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Mechanism and effect of esculetin in an experimental animal model of inflammatory bowel disease
(2013-05-01)
Esculetin is a coumarin derivative with high antioxidant activity. In a rat experimental model of inflammatory bowel disease induced by trinitrobenzenesulfonic acid, esculetin at the dose of 5mg/Kg displayed intestinal ...
Protective role of NKT cells and macrophage M2-driven phenotype in bleomycin-induced pulmonary fibrosis
(Springer Basel Ag, 2018)
Pulmonary fibrosis is a result of an abnormal wound healing in lung tissue triggered by an excessive accumulation of extracellular matrix proteins, loss of tissue elasticity, and debit of ventilatory function. NKT cells ...
Critical involvement of Th1-related cytokines in renal injuries induced by ischemia and reperfusion
(Elsevier B.V., 2009-06-01)
Renal ischemia and reperfusion injury (IRI) is considered an inflammatory syndrome. To move forward in its pathogenesis, we exploited the role of several cytokines on renal damages triggered by IRI. Specifically to evaluate ...
Effect of cyclosporin A on nitric oxide production in cultured LLC-PK1 cells
(Marcel Dekker Inc, 2001-01-01)
The effect of Cyclosporin A on nitric oxide production was studied in cultured LLC- PK1 cells. for this purpose the cells were incubated with vehicle (olive oil, 10 mug/ml in DMSO), Cyclosporin A (CsA, 10 mug/ml), tumor ...
Evaluation of transformation growth factor beta(1), interleukin-10, and interferon-gamma in male symptomatic and asymptomatic dogs naturally infected by Leishmania (Leishmania) chagasi
(Elsevier B.V., 2007-02-28)
The aims of this study were to evaluate the immunomodulatory role of TGF-beta(1), 1L-10, and INF-gamma in spleen and liver extracts and supernatant cultures of white spleen cells from male symptomatic and asymptomatic dogs, ...
Perforin and Gamma Interferon Expression Are Required for CD4(+) and CD8(+) T-Cell-Dependent Protective Immunity against a Human Parasite, Trypanosoma cruzi, Elicited by Heterologous Plasmid DNA Prime-Recombinant Adenovirus 5 Boost Vaccination
(Amer Soc Microbiology, 2009-10-01)
A heterologous prime-boost strategy using plasmid DNA, followed by replication-defective recombinant adenovirus 5, is being proposed as a powerful way to elicit CD4(+) and CD8(+) T-cell-mediated protective immunity against ...
Tumor-associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma
(2013-03-01)
Objective: To evaluate and characterize macrophage populations (M1/M2) in the tumor microenvironment of oral cavity squamous cell carcinoma (OCSCC). The relationship between macrophages and clinicopathological factors, ...
Production of IFN-gamma is impaired in patients with paracoccidioidomycosis during active disease and is restored after clinical remission
(B I O S Scientific Publishers Ltd, 2000-06-01)
Cellular immunity is usually suppressed during paracoccidioidomycosis (PCM) and is restored after treatment. in this study we evaluated the induction of a type 1 (interferon gamma (IFN-gamma)), a type 2 (interleukin (IL)-10) ...
Sepse por Salmonella associada à deficiência do receptor da Interleucina-12 (IL-12Rbeta1)
(Sociedade Brasileira de Pediatria, 2003-06-01)
OBJECTIVE: to present a case report of a child who developed sepsis by Salmonella enteritidis associated with the diagnosis of primary immunodeficiency. DESCRIPTION: a twenty-one months old boy presenting fever and skin ...