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Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro
(2013-06-01)
Annexin A1 (AnxA1) is a protein that displays potent anti-inflammatory properties, but its expression in eye tissue and its role in ocular inflammatory diseases have not been well studied. We investigated the mechanism of ...
Subsites of trypsin active site favor catalysis or substrate binding
(Elsevier B.V., 2002-01-11)
Enzymes enhance chemical reaction rates by lowering the activation energy, the energy barrier of the reaction leading to products. This occurs because enzymes bind the high-energy intermediate of the reaction (the transition ...
Controlled hydrolysis of cheese whey proteins using trypsin and alpha-chymotrypsin
(Humana Press Inc, 2001-03-01)
This study examined the production of protein hydrolysates with controlled composition from cheese whey proteins. Cheese whey was characterized and several hydrolysis experiments were made using whey proteins and purified ...
Thimet oligopeptidase and the stability of MHC class I epitopes in macrophage cytosol
(Academic Press Inc, 1999-02-24)
In this study we investigated the fate of a class of proteasome-generated oligopeptides, exposing them to the crude cytosol of macrophages or to the purified recombinant thimet oligopeptidase. Among the proteasome products ...
Mecanismos de ação e controle da digestão de proteínas e peptídios em humanos
(1999-12-01)
This review aims to report the major control mechanisms of protein and peptides digestion of special interest in human patients. Regarding protein assimilation its digestive process begins at the stomach with some not so ...
Subsite substrate specificity of midgut insect chymotrypsins
(Elsevier B.V., 2008-06-01)
Insect chymotrypsins are distinctively sensitive to plant protein inhibitors, suggesting that they differ in subsite architecture and hence in substrate specificities. Purified digestive chymotrypsins from insects of three ...