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Mostrando ítems 11-20 de 241
Ionotropic but not metabotropic glutamatergic receptors in the locus coeruleus modulate the hypercapnic ventilatory response in unanaesthetized rats
(2013-05-01)
Aim: Central chemoreceptors are important to detect changes of CO2/H+, and the Locus coeruleus (LC) is one of the many putative central chemoreceptor sites. Here, we studied the contribution of LC glutamatergic receptors ...
Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
(Electrochemical Science Group, 2010-10-01)
The poly-L-glutamic acid (PGA), was used a biodegradable polymers as conjugated to doxorubicin (DXR) and also in the modification glassy carbon electrode. The interaction operate via terminal amino groups of the drug and ...
Application of a glassy carbon electrode modified with poly(glutamic acid) in caffeic acid determination
(Springer, 2005-09-01)
Glassy carbon electrodes were coated with films of poly( glutamic acid) ( PG), and the modified electrode proved to be very effective in the oxidation of caffeic acid. The performance of the film was also tested with ...
Role of glutamate NMDA receptors and nitric oxide located within the periaqueductal gray on defensive behaviors in mice confronted by predator
(Springer, 2009-07-01)
The midbrain periaqueductal gray (PAG) is part of the brain system involved in active defense reactions to threatening stimuli. Glutamate N-methyl-d-aspartate (NMDA) receptor activation within the dorsal column of the PAG ...
Cardiovascular responses to microinjection of L-glutamate into the NTS in AV3V-lesioned rats
(Elsevier B.V., 2004-10-29)
The excitatory amino acid L-glutamate injected into the nucleus of the solitary tract (NTS) in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure (MAP) and reduces heart ...
Ionotropic glutamatergic receptors in the rostral medullary raphe modulate hypoxia and hypercapnia-induced hyperpnea
(Elsevier B.V., 2011-01-31)
It has been suggested that the medullary raphe (MR) plays a key role in the physiological responses to hypoxia and hypercapnia. We assessed the role of ionotropic glutamate receptors in the rostral MR (rMR) in the respiratory ...
Simple electroanalytical method for determination of guanosine in biological sample
(2010-12-01)
A poly glutamic acid film modified electrode exhibited a catalytic response toguanosine oxidation potential and higher peak current value. Linear concentration curve was obtained in the concentration interval of 1.0 a 10.0 ...
Cocaine-induced behavioral sensitization in adolescent rats endures until adulthood: Lack of association with GluR1 and NR1 glutamate receptor subunits and tyrosine hydroxylase
(Pergamon-Elsevier B.V. Ltd, 2008-11-01)
Exposure to repeated cocaine induces enduring behavioral sensitization, which has been implicated in the psychostimulant-induced craving and psychosis. Adaptations in dopamine and glutamate neurotransmission in the nucleus ...
Glutamate-induced obesity leads to decreased sperm reserves and acceleration of transit time in the epididymis of adult male rats
(Biomed Central Ltd., 2012-12-05)
Background: Given the established fact that obesity interferes with male reproductive functions, the present study aimed to evaluate sperm production in the testis and storage in the epididymis in a glutamate-induced model ...