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Down-modulation of lymphoproliferation and interferon-gamma production by beta-glucan derived from Saccharomyces cerevisiae
(Instituto Oswaldo Cruz, Ministério da Saúde, 2003-12-01)
beta-glucan, one of the major cell wall components of Saccharomyces cerevisiae, has been found to enhance immune functions. This study investigated in vivo and in vitro effects of beta-glucan on lymphoproliferation and ...
Endogenous accumulation of IFN-gamma in IFN-gamma-R-/- mice increases resistance to B16F10-Nex2 murine melanoma: a model for direct IFN-gamma anti-tumor cytotoxicity in vitro and in vivo
(Taylor & Francis As, 2002-06-01)
Syngeneic IFN-gamma - / - and IRF-1 - / - mice are very sensitive to B16F10-Nex2 murine melanoma cells implanted subcutaneously. in contrast, IFN-gamma-R - / - (GRKO) mice are remarkably resistant to tumor development. ...
Effect of interleukin-10 on the Paracoccidioides brasiliensis killing by gamma-interferon activated human neutrophils
(Center Academic Publ Japan, 2007-01-01)
Paracoccidioidomycosis, a deep mycosis endemic in Latin America, is a chronic granulomatous disease caused by the fungus Paracoccidioides brasiliensis. Phagocytic cells play a critical role against this fungus, and several ...
Interferon-gamma+874 Polymorphism in the First Intron of the Human Interferon-gamma Gene and Kidney Allograft Outcome
(Elsevier B.V., 2010-12-01)
Background. Despite advances in immunosuppressive therapy in the past decade, allograft rejection remains an important cause of kidney graft failure. Cytokines play a major role in the inflammatory and immune responses ...
Expression of CD40 ligand, interferon-gamma and Fas ligand genes in endomyocardial biopsies of human cardiac allografts: correlation with acute rejection
(Associação Brasileira de Divulgação Científica, 2001-06-01)
The purpose of the present study was to investigate the expression (mRNA) of CD40 ligand (CD40L), interferon-gamma (IFN-gamma) and Fas ligand (FasL) genes in human cardiac allografts in relation to the occurrence of acute ...
Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis: activation of CD8(+) cells, interferon-gamma recovery and reduction of lung injury
(Blackwell Publishing, 2004-09-01)
A DNA vaccine based on the heat-shock protein 65 Mycobacterium leprae gene (pHSP65) presented a prophylactic and therapeutic effect in an experimental model of tuberculosis. In this paper, we addressed the question of which ...
Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells
(Pergamon-Elsevier Science Ltd, 2018)
The wake-promoting drug Modafinil has been used for treatment of sleep disorders, such as Narcolepsy, excessive daytime sleepiness and sleep apnea, due to its stimulant action. Despite the known effect of Modafinil on brain ...
Retinal pigment epithelial cells are heterogeneous in their expression of MHC-II after stimulation with interferon-gamma
(Academic Press Ltd, 1999-04-01)
The pattern of interferon-gamma-induced major histocompatibility complex Class II antigen expression was evaluated on the retinal pigment epithelium. Experiments were performed in vitro using explant cultures of aged and ...
Fungicidal activity of human monocyte-derived multinucleated giant cells induced in vitro by Paracoccidioides brasiliensis antigen
(Springer, 2008-07-01)
Multinucleated giant cells (MGC) are characteristic cells in granulomatous disorders such as paracoccidioidomycosis (PCM) and also are formed in vitro from peripheral blood mononuclear cells by several stimuli. In this ...
Effects of synbiotic-based Bifidobacterium animalis in female rats experimentally infected with Toxoplasma gondii
(Elsevier B.V., 2011-03-01)
The aim of this study was to assess the effects of a synbiotic composed of Bifidobacterium animalis and fructooligosaccharides on female rats infected with Toxoplasma gondii. Female Wistar rats, treated or not with ...