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Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking.
(2019)
Chronic ethanol consumption leads to brain oxidative stress and neuroinflammation,
conditions known to potentiate and perpetuate each other. Several studies have shown that neuroinflammation results in increases in chronic ...
Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options
(2019)
Background: Chronic consumption of most drugs of abuse leads to brain oxidative stress and neuroinflammation, which inhibit the glutamate transporter GLT-1, proposed to perpetuate drug intake. The present study aimed at ...
Acellular derivatives of mesenchymal stem cells prevent peritoneal adhesions in an animal model
(2018)
Background: Peritoneal adhesions are nonanatomical connections that bind organs to the
abdominal wall or among them. They arise after peritoneal injury, which triggers an inflammatory response followed by a healing process ...
Small Extracellular Vesicles Released from Ovarian Cancer Spheroids in Response to Cisplatin Promote the Pro-Tumorigenic Activity of Mesenchymal Stem Cells
(MDPI, 2019)
Despite the different strategies used to treat ovarian cancer, around 70% of women/patients eventually fail to respond to the therapy. Cancer stem cells (CSCs) play a role in the treatment failure due to their chemoresistant ...
Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma
(2019)
Recently, exosomes secreted by menstrual mesenchymal stem cells have been identified as inhibitory agents of tumor angiogenesis and modulators of the tumor cell secretome in prostate and breast cancer. However, their direct ...
Gilz-Activin A as a Novel Signaling Axis Orchestrating Mesenchymal Stem Cell and Th17 Cell Interplay
(2018)
Mesenchymal stem cells (MSC) are highly immunosuppressive cells able to reduce chronic inflammation through the active release of mediators. Recently, we showed that glucocorticoid-induced leucine zipper (Gilz) expression ...
Current status of mesenchymal stem/stromal cells for treatment of neurological diseases
(Frontiers Media, 2022)
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model
(Public Library of Science, 2018)