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Radicicol improves regeneration of skeletal muscle previously damaged by crotoxin in mice
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
This work investigates the influence of heat shock proteins (HSPs) on necrosis and subsequent skeletal muscle regeneration induced by crotoxin (CTX), the major component of Crotalus durissus terrificus venom. Mice were ...
OCT4 expression mediates partial cardiomyocyte reprogramming of mesenchymal stromal cells
(Public Library of Science, 2017-12)
Mesenchymal stem/stromal cells (MSCs) are in numerous cell therapy clinical trials, including for injured myocardium. Acquisition of cardiomyocyte characteristics by MSCs may improve cardiac regeneration but the mechanisms ...
Role of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1
(Wiley-Liss, 2014)
In the heart, insulin‐like growth factor‐1 (IGF‐1) is a peptide with pro‐hypertrophic and anti‐apoptotic actions. The pro‐hypertrophic properties
of IGF‐1 have been attributed to the extracellular regulated kinase (ERK) ...
Diet-induced obesity causes metabolic, endocrine and cardiac alterations in spontaneously hypertensive rats
(Int Scientific Literature, Inc, 2010-12-01)
Background: Although obesity has been associated with several effects in rodents, few investigations have evaluated the metabolic, endocrine, and cardiac parameters of spontaneously hypertensive rats (SHR) with dietary-induced ...
Intense resistance training induces pronounced metabolic stress and impairs hypertrophic response in hind-limb muscles of rats
(Taylor & Francis Ltd, 2019-04-01)
Skeletal muscle hypertrophy is an exercise-induced adaptation, particularly in resistance training (RT) programs that use large volumes and low loads. However, evidence regarding the role of rest intervals on metabolic ...
Influence of intermittent fasting on myocardial infarction-induced cardiac remodeling
(2019-05-28)
Background: Information on the role of intermittent fasting (IF) on pathologic cardiac remodeling is scarce. We compared the effects of IF before and after myocardial infarction (MI) on rat cardiac remodeling and survival. ...
Diabetes mellitus activates fetal gene program and intensifies cardiac remodeling and oxidative stress in aged spontaneously hypertensive rats
(Biomed Central Ltd., 2013-10-17)
Background: The combination of systemic arterial hypertension and diabetes mellitus (DM) induces greater cardiac remodeling than either condition alone. However, this association has been poorly addressed in senescent rats. ...
Prevalence of the E321G MYH1 variant in Brazilian Quarter Horses
(2021-01-01)
Background: In the Quarter Horse (QH), myosin heavy chain myopathy (MYHM), which is characterised by nonexertional rhabdomyolysis or immune-mediated myositis (IMM) with acute muscle atrophy, is strongly associated with the ...
AT1 receptor blockade attenuates insulin resistance and myocardial remodeling in rats with diet-induced obesity
(2014-01-23)
Background: Although obesity has been associated with metabolic and cardiac disturbances, the carrier mechanisms for these responses are poorly understood. This study analyzed whether angiotensin II blockade attenuates ...
Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets
(2010-07-01)
Background: This study tested whether rats with obesity induced by a hypercaloric diet (HD) present higher nutritional, endocrine, and cardiovascular disturbances compared with counterparts with obesity induced by overfeeding ...