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Autoimmunity in common variable immunodeficiency
(SPRINGER/PLENUM PUBLISHERS, 2008)
immunodeficiency (CVID), the most common symptomatic primary immunodeficiency in adulthood. Different authors report high prevalences of autoimmune diseases in CVID, and several mechanisms have been proposed to explain ...
Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome
(Bentham Science Publishers, 2015-08)
Nonalcoholic fatty liver disease (NAFLD) is defined as the accumulation of triglycerides (TGs) within hepatocytes exceeding 5 % of liver weight. NAFLD is a spectrum of pathological processes from nonalcoholic fatty liver ...
The profile and contribution of rare germline copy number variants to cancer risk in Li-Fraumeni patients negative for TP53 mutations
(BioMed CentralLondon, 2014-04-28)
Background: The Li-Fraumeni syndrome (LFS) is an inherited rare cancer predisposition syndrome characterized by
a variety of early-onset tumors. Although germline mutations in the tumor suppressor gene TP53 account for ...
Type-2 diabetes mellitus and the frequency of the G22A polymorphism of the adenosine deaminase gene in a mixed population in Brazil
(Oxford University Press, 2014-07-01)
Most individuals diagnosed with diabetes mellitus (about 90%) have type 2 disease (T2DM). T2DM is associated with a high genetic predisposition and is characterized by changes in the secretion and action of insulin. There ...
Functional haplotypes in interleukin 4 gene associated with periodontitis
(2017-01-01)
Chronic periodontitis (CP) is an infectious inflammatory disease that affects tooth-supporting structures and in which dental plaque bacteria, immune mechanisms and genetic predisposition play important roles. Interleukin ...
Novel tactics for neuroprotection in Parkinson's disease: Role of antibiotics, polyphenols and neuropeptides
(Pergamon-Elsevier Science Ltd, 2017-08)
Parkinson's disease is a progressive neurodegenerative disorder characterized by the degeneration of midbrain nigral dopaminergic neurons. Although its etiology remains unknown, the pathological role of several factors has ...
Frequency of concurrent autoimmune disorders in patients with autoimmune hepatitis - Effect of age, gender, and genetic background
(LIPPINCOTT WILLIAMS & WILKINS, 2008)
Background: Concurrent autoimmune disorders (CAIDs) have been shown to occur in 22% to 34% of the patients with autoimmune hepatitis (AIH). Their presence has been linked to female gender, older age, and to certain HLA ...
Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?
(Munksgaard Int Publ LtdCopenhagenDinamarca, 1998)
Germline DNA copy number variation in familial and early-onset breast cancer
(BIOMED CENTRAL LTDLONDON, 2012)
Introduction: Genetic factors predisposing individuals to cancer remain elusive in the majority of patients with a familial or clinical history suggestive of hereditary breast cancer. Germline DNA copy number variation ...
Síndrome metabólica: o novo desafio da Nutrição
(São Paulo, 2010)
A síndrome metabólica (SM) consiste em um conjunto de fatores de risco cardiovascular relacionados à obesidade abdominal e à resistência à insulina, refletindo no aumento da glicemia e da pressão arterial e na ocorrência ...