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Sistemas para liberação colônica: Uma alternativa para a veiculação de fármacos para efeito local ou sistêmico
(2001-12-01)
Problems related to the systemic administration of drugs, such as biodistribution, difficulty of targeting, necessity of high doses to achieve adequate levels of the drug in specific sites, toxicity, and undesirable side ...
Polysaccharide-based nanocarriers for ocular drug delivery
(Bentham Science Publishers, 2015-10)
Obtaining successful ocular formulations able to support an efficient drug concentration at the target tissue for an appropriate period of time is an interesting challenge for modern pharmaceutical technology. In this ...
Ketoconazole in the treatment of experimental murine paracoccidioidomycosis
(1987-01-01)
In a murine model of chronic disseminated paracoccidioidomycosis (strain 18; intravenous route), Ketoconazole (200 mg/kg in 0.2% agar) was given daily by gavage in three different schedules. Continuous treatment from an ...
Perspectives for Novel Mixed Diruthenium-Organic Drugs as Metallopharmaceuticals in Cancer Therapy
(BENTHAM SCIENCE PUBL LTD, 2010)
Ruthenium compounds have been actively studied as metallodrugs for cancer therapy. Representatives of ruthenium-based antitumor drugs are the classes of ruthenium(III)-chlorido-(N-ligand)complexes, including the drugs ...
Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline
(Massachusetts Medical Society, 2014)
Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when added to a ...
Applications of Nanosystems to Anticancer Drug Therapy (Part II. Dendrimers, Micelles, Lipid-based Nanosystems)
(Bentham Science Publishers, 2014-01)
The great efforts of many researchers have brought down some of the barriers that exist to turn a good in vitro compound into a potential in vivo drug. The advent of pharmaceutical nanotechnology has allowed an arsenal of ...