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Mostrando ítems 61-70 de 99
Potential Therapies to Protect the Aging Heart Against Ischemia/Reperfusion Injury
(Frontiers Media, 2021)
Despite important advances in the treatment of myocardial infarction that have significantly reduced mortality, there is still an unmet need to limit the infarct size after reperfusion injury in order to prevent the onset ...
High-Dose Plasmid-Mediated VEGF Gene Transfer is Safe in Patients With Severe Ischemic Heart Disease (GENESIS-I): A Phase I, Open-Label, Two-Year Follow-up Trial
(Wiley, 2013-11-15)
Objectives: We aimed to assess safety and, secondarily, the efficacy of intramyocardial high-dose plasmid-vascular endothelial growth factor (VEGF) 165 (pVEGF165) gene transfer in no-option patients with coronary artery ...
Antioxidant cardioprotection against reperfusion injury: potential therapeutic roles of resveratrol and quercetin
(MDPI, 2022)
Ischemia-reperfusion myocardial damage is a paradoxical tissue injury occurring during percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients. Although this damage could account for up to ...
Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death
(Public Library Science, 2016)
Inhibitors of the ubiquitin-proteasome system improve hemodynamic parameters and decrease the infarct size after ischemia reperfusion. The molecular basis of this protection is not fully understood since most available ...
Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatory factors.
(2010-11-30)
Although intrinsic skeletal muscle abnormalities can influence exercise intolerance during heart failure (HF), the factors responsible for muscle changes have not been elucidated. In this study we evaluated the expression ...
Cardiac remodeling induced by smoking: Concepts, relevance, and potential mechanisms
(2012-12-04)
Cardiac or ventricular remodeling is characterized by molecular, cellular, and interstitial alterations that lead to changes in heart size, mass, geometry and function in response to a given insult. Currently, tobacco smoke ...
ECG scar quantification correlates with cardiac magnetic resonance scar size and prognostic factors in Chagas' disease
(B M J PUBLISHING GROUP, 2011)
Objective To test the hypothesis that 12-lead ECG QRS scoring quantifies myocardial scar and correlates with disease severity in Chagas' heart disease. Design Patients underwent 12-lead ECG for QRS scoring and cardiac ...