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Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS
(BMC, 2021)
Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects motoneurons. Mutations in superoxide dismutase 1 (SOD1) have been described as a causative genetic factor for ALS. Mice ...
Phylogenetic inheritance of genetic variability produced by neutral models of evolution
(Funpec-editoraRibeirao PretoBrasil, 2008)
Differential evolution using ancestor tree for service restoration in power distribution systems
(Elsevier B.V.Amsterdam, 2014-10)
Problems in power distribution system reconfiguration (PDSR), such as service restoration, power loss reduction, and expansion planning, are usually formulated as complex multi-objective and multi-constrained optimization ...
The Endoplasmic Reticulum Glucosyltransferase Recognizes Nearly Native Glycoprotein Folding Intermediates
(American Society for Biochemistry and Molecular Biology, 2004-10)
The UDP-Glc:glycoprotein glucosyltransferase (GT), a key player in the endoplasmic reticulum (ER) quality control of glycoprotein folding, only glucosylates glycoproteins displaying non-native conformations. To determine ...
Folding of a cyclin box: linking multitarget binding to marginal stability, oligomerization, and aggregation of the retinoblastoma tumor suppressor AB pocket domain
(American Society For Biochemistry And Molecular Biology, 2013-06)
The retinoblastoma tumor suppressor (Rb) controls the proliferation, differentiation, and survival of cells in most eukaryotes with a role in the fate of stem cells. Its inactivation by mutation or oncogenic viruses is ...
Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates Notch-induced tumourigenesis
(Public Library Science, 2013-05-07)
Fine-tuned Notch and Hedgehog signaling pathways via attenuators and dampers have long been recognized as important<br />mechanisms to ensure the proper size and differentiation of many organs and tissues. This notion is ...
Drug resistance in Mycobacterium tuberculosis clinical isolates from Brazil: Phenotypic and genotypic methods
(Elsevier France-editions Scientifiques Medicales Elsevier, 2011-09-01)
We determined the susceptibility profile of 80 Mycobacterium tuberculosis (MTB) clinical isolates from Brazil against isoniazid (INH) and rifampicin (RIF) drugs by two phenotypic methods (Resazurin Microtiter Assay -REMA ...
The CpxR/CpxA system contributes to Salmonella gold-resistance by controlling the GolS-dependent gesABC transcription
(Wiley Blackwell Publishing, Inc, 2017-10)
Several regulatory systems contribute to bacterial resistance to heavy metals controlling the expression of factors required to eliminate the intoxicant and/or to repair the damage caused by it. In Salmonella, the response ...