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Lysophosphatidic acid increases the production of pivotal mediators of decidualization and vascularization in the rat uterus
(Elsevier, 2013-06)
Introduction: The decidual reaction and the formation of new vessels in the uterus are two crucial processes during embryo implantation. Previously, we observed that lysophosphatidic acid (LPA) increases cyclooxygenase-2 ...
Augmented nitric oxide production and up-regulation of endothelial nitric oxide synthase during cecal ligation and perforation
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2012)
Nitric oxide (NO) has been pointed out as being the main mediator involved in the hypotension and tissue injury taking place during sepsis. This study aimed to investigate the cellular mechanisms implicated in the acetylcholine ...
Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and beta-pinene: Involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E-2
(Elsevier B.V., 2011-01-15)
Citrus lemon (CL) belongs to Rutaceae family and is popularly known in Brazil as lima() siciliano. The phytochemical analysis of CL fruit bark essential oil showed two majority components, limonene (LIM) and beta-pinene ...
Chronic ouabain treatment exacerbates blood pressure elevation in spontaneously hypertensive rats: the role of vascular mechanisms
(LIPPINCOTT WILLIAMS & WILKINS, 2009)
Objective Hypertensive rats are more sensitive to the pressor effects of acute ouabain than normotensive rats. We analyzed the effect of chronic ouabain (similar to 8.0 mu g/day, 5 weeks) treatment on the blood pressure ...
ACTIVATION OF PERIPHERAL kappa/delta OPIOID RECEPTORS MEDIATES 15-DEOXY-(Delta 12,14)-PROSTAGLANDIN J(2) INDUCED-ANTINOCICEPTION IN RAT TEMPOROMANDIBULAR JOINT
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
This study assessed the effect of the agonist 15d-PGJ(2) administered into the rat temporomandibular joint (TMJ) on nociceptive behavioral and the anti-inflammatory potential of this prostaglandin on TMJ. It was observed ...
Chronic methionine load-induced hyperhomocysteinemia impairs the relaxation induced by bradykinin in the isolated rat carotid
(SPRINGER, 2009)
This study investigates the effects of chronic methionine intake on bradykinin (BK)-relaxation. Vascular reactivity experiments were performed on carotid rings from male Wistar rats. Treatment with methionine (0.1, 1 or 2 ...
A lipocalin sequence signature modulates cell survival
(ELSEVIER SCIENCE BV, 2010)
Lipocalins are beta-barrel proteins, which share three conserved motifs in their amino acid sequence. In this study, we identified by a peptide mapping approach, a seven-amino acid sequence related to one of these motifs ...
Effect of dipyrone, L-NAME and L-arginine on endotoxin-induced rat paw edema
(1996-11-01)
Paw edema was induced in male Wistar rats (200-250 g) by intraplantar (ipl) administration of 2.5 μg endotoxin (Etx). Etx, like carrageenin, produced two distinct edema formation phases, an early phase (75 min) followed ...