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Molecular mechanisms of the induction of IL-12 and its inhibition by IL- 10
(1998-06-15)
Exogenously added IL-10 rapidly inhibited Staphylococcus aureus- or LPS- induced cytokine mRNA expression in human PBMCs and monocytes, with a maximal effect observed when IL-10 was added from 20 h before until 1 h after ...
Sympathetic outflow activates the venom gland of the snake Bothrops jararaca by regulating the activation of transcription factors and the synthesis of venom gland proteins
(COMPANY OF BIOLOGISTS LTD, 2009)
The venom gland of viperid snakes has a central lumen where the venom produced by secretory cells is stored. When the venom is lost from the gland, the secretory cells are activated and new venom is produced. The production ...
YebC, a putative transcriptional factor involved in the regulation of the proteolytic system of Lactobacillus
(Nature Publishing Group, 2017-12-17)
The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. ...
Transcription Factor CREB3L1 Regulates Vasopressin Gene Expression in the Rat Hypothalamus
(Soc Neuroscience, 2014-03-12)
Arginine vasopressin (AVP) is a neurohypophysial hormone regulating hydromineral homeostasis. Here we show that the mRNA encoding cAMP responsive element-binding protein-3 like-1 (CREB3L1), a transcription factor of the ...
Epigenetics regulates transcription and pathogenesis in the parasite Trichomonas vaginalis
(Wiley Blackwell Publishing, Inc, 2017-06)
Trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract. Infections range from asymptomatic to highly inflammatory, depending on the host and the parasite strain. Different ...
The GATA3 gene is involved in leprosy susceptibility in Brazilian patients
(ScienceDirect, 2016-04)
Leprosy outcome is a complex trait and the host-pathogen-environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region ...
NFAT activation by membrane potential follows a calcium pathway distinct from other activity-related transcription factors in skeletal muscle cells
(AMER PHYSIOLOGICAL SOC, 2008-03)
Depolarization of skeletal muscle cells triggers intracellular calcium signals mediated by
ryanodine and IP3 receptors. We have reported that K+-induced depolarization activates the
transcriptional regulators ERKs, CREB, ...
Oxidative Stress Alters the Profile of Transcription Factors Related to Early Development on in Vitro Produced Embryos
(2017-01-01)
High oxygen levels during in vitro culture (IVC) can induce oxidative stress through accumulation of reactive oxygen species (ROS), negatively affecting embryo development. This study evaluated the effect of different O 2 ...