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Cytokine gene variants and venous thrombotic risk in the BRATROS (BRAZILIAN THROMBOSIS STUDY)
(2007-05-21)
Introduction: Venous thrombosis (VT) and inflammation are two closely related entities. In the present investigation we assessed whether there is a relation between genetic modifiers of the inflammatory response and the ...
Cloning of hif-1alpha and hif-2alpha and mRNA expression pattern during development in zebrafish
(Elsevier, 2007-01)
Hypoxia-inducible factors (HIFs) regulate gene expression in response to hypoxia and in vertebrates they are known to participate in several developmental processes, including angiogenesis, vasculogenesis, heart and central ...
Neuronal HIF-1 alpha in the nucleus tractus solitarius contributes to ventilatory acclimatization to hypoxia
(Wiley-Blackwell Publishing Ltd, 2020-05)
We hypothesized that hypoxia inducible factor 1 alpha (HIF-1 alpha) in CNS respiratory centres is necessary for ventilatory acclimatization to hypoxia (VAH); VAH is a time-dependent increase in baseline ventilation and the ...
The role of local and systemic renin angiotensin system activation in a genetic model of sympathetic hyperactivity-induced heart failure in mice
(AMER PHYSIOLOGICAL SOC, 2008)
Sympathetic hyperactivity (SH) and renin angiotensin system (RAS) activation are commonly associated with heart failure (HF), even though the relative contribution of these factors to the cardiac derangement is less ...
Early weaning accelerates the differentiation of mucous neck cells in rat gastric mucosa: Possible role of TGF alpha/EGFR
(ELSEVIER SCI LTD, 2010)
The development of the gastric mucosa is controlled by hormones, growth factors and feeding behavior. Early weaning (EW), which means the abrupt interruption of suckling, increases proliferation and differentiation in the ...
Is there a role for TNF-alpha antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi technique
(Clinical & Exper RheumatologyPisaItália, 2011)
Changes in calsequestrin, TNF-alpha, TGF-beta and MyoD levels during the progression of skeletal muscle dystrophy in mdx mice: a comparative analysis of the quadriceps, diaphragm and intrinsic laryngeal muscles
(Wiley-Blackwell, 2015-10-01)
In Duchenne muscular dystrophy (DMD), the search for new biomarkers to follow the evolution of the disease is of fundamental importance in the light of the evolving gene and pharmacological therapies. In addition to the ...
Tnf-alpha-mediated Cardiorenal Injury After Rhabdomyolysis In Rats
(AMER PHYSIOLOGICAL SOCBETHESDA, 2015)
Influence of Yersinia pseudotuberculosis outer proteins (Yops) on interleukin-12, tumor necrosis factor alpha and nitric oxide production by peritoneal macrophages
(Elsevier B.V., 2004-06-15)
An essential key to pathogenicity in Yersinia is the presence of a 70 kb plasmid (pYV) which encodes a type-III secretion system and several virulence outer proteins whose main function is to enable the bacteria to survive ...