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Hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death
(2006)
NFκB is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NFκB pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase and cell ...
Induction of apoptosis in A549 pulmonary cells by two Paracoccidioides brasiliensis samples
(Instituto Oswaldo Cruz, Ministério da Saúde, 2009-08-01)
Paracoccidioidomycosis presents a variety of clinical manifestations and Paracoccidioides brasiliensis can reach many tissues, most importantly the lungs. The ability of the pathogen to interact with host surface structures ...
Cytotoxicity and Antitumoral Activity by Apoptosis Induction of AC13: A Brominated Curcumin Analogue
(Wolters Kluwer Medknow Publications, 2018-10-01)
Background: Natural compounds with therapeutic potential have been explored as antitumoral agents, as curcumin (CUR), a substance which has activity against various tumor types and a tool used to improve the action of these ...
Insights into the activation of oral keratinocyte cell death by Candida albicans and Staphylococcus aureus biofilms
(2021-01-01)
Polymicrobial biofilms comprising Candida albicans and Staphylococcus aureus can increase the frequency and severity of oral diseases. This study assessed oral keratinocyte cell death, apoptosis and/or necrosis, promoted ...
Apoptosis in different gastric lesions and gastric cancer: Relationship with Helicobacter pylori, overexpression of p53 and aneuploidy
(2007-11-19)
Apoptosis has an essential function in maintaining the integrity of the gastrointestinal mucosa. Its deregulation is associated with the occurrence of lesions such as in atrophic gastritis, peptic ulcers, intestinal ...
Th-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis
(American Association for Cancer Research, 2013-03-27)
Neuroblastoma, the most common extracranial pediatric solid tumor, is responsible for 15% of all childhood cancer deaths. Patients frequently present at diagnosis with metastatic disease, particularly to the bone marrow ...
Disorders of apoptosis: Mechanisms for autoimmunity in primary immunodeficiency diseases
(SPRINGER/PLENUM PUBLISHERS, 2008)
A number of primary immunodeficiency diseases represent a paradox of immunodeficiency and autoimmunity. In this minireview, we present basic concepts of apoptosis and disorder of apoptosis as one of the mechanisms to explain ...
Liver damage and caspase-dependent apoptosis is related to protein malnutrition in mice: Effect of methionine
(Elsevier Gmbh, 2014-11)
This study aimed to determine whether the effects on the mouse liver caused by three periods of feeding a protein-free diet for 5 days followed by a normal complete diet for 5 days (3PFD-CD) are prevented by a constant ...