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Affinity Maturation Increases the Stability and Plasticity of the Fv Domain of Anti-protein Antibodies
(Elsevier, 2007-09)
The somatic mutations accumulated in variable and framework regions of antibodies produce structural changes that increase the affinity towards the antigen. This implies conformational and non covalent bonding changes at ...
The heminested RT-PCR for the study of rabies virus pathogenesis
(Elsevier B.V., 2005-03-01)
The aim of the present trial was to evaluate the heminested RT-PCR for the study of rabies virus distribution in mice inoculated experimentally. Inoculation was by the intramuscular route in 150 mice, using the dog street ...
A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom
(2014-09-01)
BaP1 is a P-I class snake venom metalloproteinase (SVMP) relevant in the local tissue damage associated with envenomings by Bothrops asper, a medically important snake species in Central America and parts of South and North ...
Correct targeting of proinsulin in protein storage vacuoles of transgenic soybean seeds
(Funpec-editoraRibeirao PretoBrasil, 2010)
Exposure to rabies virus in a population of free-ranging capuchin monkeys (Cebus apella nigritus) in a fragmented, environmentally protected area in southeastern Brazil
(Springer Tokyo, 2012-07-01)
The aim of this study is to assess the frequency of rabies antibodies in free-ranging capuchin monkeys (Cebus apella nigritus) in a fragmented, environmentally protected, rural area of southeastern Brazil. Thirty-six ...
Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom
(1998-11)
Local tissue damage represents a serious consequence of Bothrops asper envenomations. It encompasses a complex series of alterations, including myonecrosis, dermonecrosis, hemorrhage and edema. Due to its rapid development ...
Specific macromolecular interactions between tau and the microtubule system
(Kluwer Academic Publishers, 1992)
The microtubule-associated protein Tau, a major component of brain microtubules, shares common repeated C-terminal sequences with the high molecular-weight protein MAP-2. It has been shown that tau peptides V187-G204 and ...
Pitfalls to avoid when using phage display for snake toxins
(2017-02)
Antivenoms against bites and stings from snakes, spiders, and scorpions are associated with immunological side effects and high cost of production, since these therapies are still derived from the serum of hyper-immunized ...