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Trend analysis of carbapenem-resistant Gram-negative bacteria and antimicrobial consumption in the post-COVID-19 era: an extra challenge for healthcare institutions
(2022-02-01)
The incidence density trend of the carbapenem-resistant Gram-negative bacteria was analysed in device-associated infections and antimicrobial consumption in 99 critical care facilities in a low/middle-income country, between ...
Ampicillin/sulbactam compared with polymyxins for the treatment of infections caused by carbapenem-resistant Acinetobacter spp.
(OXFORD UNIV PRESS, 2008)
Background: There has been an increase in worldwide infections caused by carbapenem-resistant Acinetobacter. This poses a therapeutic challenge as few treatment options are available. Objectives: The aim of this study was ...
Effectiveness of castor oil extract on Escherichia coli and its endotoxins in root canals
(2012-07-01)
The results of the present study showed a significant decrease in the number of E. coli in root canals (first collection) after irrigation with castor oil extract during biomechanical preparation. All medications tested ...
EFFECT OF 4-AMINOPYRIDINE ON THE POSTSYNAPTIC ACTION OF POLYMYXIN-B
(Elsevier Science BvAmsterdamHolanda, 1989)
Polymyxin B increases the depletion of T regulatory cell induced by purinergic agonist
(Elsevier, 2012)
Regulatory T cells (Treg) are important in the development of immune tolerance under normal physiological
conditions. However, in pathological situations such as cancer, Treg increases have been correlated
with bad ...
Role of Heme Oxygenase-1 in Polymyxin B-Induced Nephrotoxicity in Rats
(AMER SOC MICROBIOLOGYWASHINGTON, 2012)
Polymyxin B (PMB) is a cationic polypeptide antibiotic with activity against multidrug-resistant Gram-negative bacteria. PMB-induced nephrotoxicity consists of direct toxicity to the renal tubules and the release of reactive ...
Efficacy of Endodontic Treatment for Endotoxin Reduction in Primarily Infected Root Canals and Evaluation of Cytotoxic Effects
(Elsevier B.V., 2012-08-01)
Introduction: Endotoxins are one of the etiologic agents involved in the pathogenesis of apical periodontitis. The objectives of this clinical study were to investigate the effects of endodontic treatment by using different ...
Design of mucoadhesive gellan gum and chitosan nanoparticles intended for colon-specific delivery of peptide drugs
(2021-11-05)
Nanotechnology has been widely used in the development of polymer nanocarriers for the oral delivery of biomolecules. The use of nanostructured systems can improve drug delivery and help to overcome the disadvantages of ...
A novel pH-responsive hydrogel-based on calcium alginate engineered by the previous formation of polyelectrolyte complexes (PECs) intended to vaginal administration
(2017-10-03)
This work aimed to develop a calcium alginate hydrogel as a pH responsive delivery system for polymyxin B (PMX) sustained-release through the vaginal route. Two samples of sodium alginate from different suppliers were ...