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Selectivity in the mechanism of action of antimicrobial mastoparan peptide Polybia-MP1
(Springer, 2008-07-01)
Many potent antimicrobial peptides also present hemolytic activity, an undesired collateral effect for the therapeutic application. Unlike other mastoparan peptides, Polybia-MP1 (IDWKKLLDAAKQIL), obtained from the venom ...
Eumenitin, a novel antimicrobial peptide from the venom of the solitary eumenine wasp Eumenes rubronotatus
(Elsevier B.V., 2006-11-01)
A novel antimicrobial peptide, eumenitin, was isolated from the venom of the solitary eumenine wasp Eumenes rubronotatus. The sequence of eumenitin, Leu-Asn-Leu-Lys-Gly-Ile-Phe-Lys-Lys-Val-Ala-Ser-Leu-Leu-Thr, was mostly ...
Interaction of antimicrobial peptide Plantaricin149a and four analogs with lipid bilayers and bacterial membranes
(Sociedade Brasileira de Microbiologia - SBMRio de Janeiro, 2013)
The amidated analog of Plantaricin149, an antimicrobial peptide from Lactobacillus plantarum NRIC 149, directly interacts with negatively charged liposomes and bacterial membranes, leading to their lysis. In this study, ...
Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation
(2020-05-01)
Increasing resistance in antibiotic and chemotherapeutic treatments has been pushing studies of design and evaluation of bioactive peptides. Designing relies on different approaches from minimalist sequences and endogenous ...
Study of mastoparan analog peptides against Candida albicans and safety in zebrafish embryos (Danio rerio)
(2019-09-01)
Aim: In this work, mastoparan analog peptides from wasp venom were tested against Candida albicans and safety assays were performed using cell culture and model zebrafish. Materials & methods: Minimal inhibitory concentration ...
Synthesis and characterization of an antibacterial and non-toxic dimeric peptide derived from the C-terminal region of Bothropstoxin-I
(Elsevier B. V., 2015)
Infectious diseases are among the leading global causes of death, increasing the search for novel antibacterial agents. Among these, biologically active peptides are an excellent research tool. Using solid-phase peptide ...
Cationic Antimicrobial Peptides Inactivate Shiga Toxin-Encoding Bacteriophages
(Frontiers Research Foundation, 2017-12)
Shiga toxin (Stx) is the principal virulence factor during Shiga toxin-producing Escherichia coli (STEC) infections. We have previously reported the inactivation of bacteriophage encoding Stx after treatment with chitosan, ...
The effects of the C-terminal amidation of mastoparans on their biological actions and interactions with membrane-mimetic systems
(Elsevier B.V., 2014-10-01)
Polycationic peptides may present their C-termini in either amidated or acidic form; however, the effects of these conformations on the mechanisms of interaction with the membranes in general were not properly investigated ...
The importance of cyclic structure for Labaditin on its antimicrobial activity against Staphylococcus aureus
(Elsevier B.V., 2016-12-01)
Antimicrobial resistance has reached alarming levels in many countries, thus leading to a search for new classes of antibiotics, such as antimicrobial peptides whose activity is exerted by interacting specifically with the ...
Purification and characterization of Hb 98-114: A novel hemoglobin-derived antimicrobial peptide from the midgut of Rhipicephalus (Boophilus) microplus
(ELSEVIER SCIENCE INCNEW YORK, 2013-08-02)
The antimicrobial activity of hemoglobin fragments (hemocidins) has been reported in a variety of models. The cattle tick Rhipicephalus (Boophilus) microplus is a blood sucking arthropod from where the first in vivo-generated ...