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Antitumor activity of Kielmeyera coriacea leaf constituents in experimental melanoma, tested in vitro and in vivo in syngeneic mice
(2014)
Purpose: The antitumor activity of Kielmeyera coriacea (Clusiaceae), a medicinal plant used in the treatment of parasitic, as well as fungal and bacterial infections by the Brazilian Cerrado population, was investigated. ...
Anti-proliferative, Anti-inflammatory, Anti-ulcerogenic And Wound Healing Properties Of Chitosan
(Bentham Science Publishers B.V., 2016)
A Novel Immunomodulatory Hemocyanin from the Limpet Fissurella latimarginata Promotes Potent Anti- Tumor Activity in Melanoma
(PLOS One, 2014)
Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as immunomodulatory proteins with
proven anti-cancer properties. The biodiversity of hemocyanins has promoted interest in identifying new ...
Anti-tumor necrosis factor-α therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis
(2005)
Objective. To assess the enzymatic activity and biochemical status of dipeptidyl peptidase IV (DPP IV), an enzyme that participates in the degradation of proinflammatory molecules, in sera from a group of patients with ...
Curcumin requires tumor necrosis Factor α signaling to alleviate cognitive impairment elicited by Lipopolysaccharide
(KargerBasel, 2013)
A decline in cognitive ability is a typical feature of the normal aging process, and of neurodegenerative disorders such as Alzheimer’s, Parkinson’s and Huntington’s diseases. Although their etiologies differ, all of these ...
Proteomics Approach of Rapamycin Anti-Tumoral Effect on Primary and Metastatic Canine Mammary Tumor Cells In Vitro
(2021-02-25)
Rapamycin is an antifungal drug with antitumor activity and acts inhibiting the mTOR complex. Due to drug antitumor potential, the aim of this study was to evaluate its effect on a preclinical model of primary mammary gland ...
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies
(Nature, 2020-06-18)
Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses immersed in aberrant communication circuits that facilitate tumor growth and dissemination. Besides the well characterized angiogenic ...
Response of the G2-prophase checkpoint to genotoxic drugs in lymphocytes from healthy individuals
(Society of Biology of Chile, 2012)
We analyzed the in vitro effects of the anti-tumoral drugs doxorubicin, cytosine arabinoside and hydroxyurea on the G2-prophase checkpoint in lymphocytes from healthy individuals. At biologically equivalent concentrations, ...
Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity
(Elsevier Ltd, 2018)
© 2018 Elsevier Ltd Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications for augmenting immune responses against cancer and infections. Previous ...
Muscarinic activation enhances the anti-proliferative effect of paclitaxel in murine breast tumor cells
(Bentham Science Publishers, 2013-10)
Muscarinic acetylcholine receptors (mAChR) are expressed in cells without nervous origin. mAChR are up-regulated in tumor cells and their stimulation can modulate tumor growth. In this work we investigated the ability of ...